通讯作者: 辛志敏, xinzhimin@ccmu.edu.cn

DOI：10.12201/bmr.202609.00004

Correlation Study on the Relationship Between Ovarian Sensitivity Index and Pregnancy Outcomes in IVF-ET

• 摘要：目的 探讨体外受精?胚胎移植（IVF?ET）中卵巢敏感性指数（OSI）对不孕患者卵巢反应性及临床妊娠率的预测价值。方法 回顾性分析在首都医科大学附属北京妇产医院/北京妇幼保健院2019.06-2019.12首次行IVF-ET/治疗的170例不孕患者，按妊娠结局分为妊娠组（80例）与未妊娠组（90例）。将单因素分析中达到统计学显著水平的特征变量纳入多重共线性检验，并进一步采用多因素Logistic回归模型筛选临床妊娠的独立预测因素。结果 单因素分析表明妊娠组年龄显著低于未妊娠组，而妊娠组的AFC、AMH、获卵数、HCG日E2及OSI水平均显著高于未妊娠组（P<0.05），各变量之间不存在共线性，多因素Logistic回归显示，OSI是临床妊娠率的独立影响因素（OR=0.72，95%CI：0.56~0.92，P=0.008）。结论 OSI可作为IVF?ET患者卵巢反应性与妊娠结局的有效预测指标。

  关键词： 卵巢敏感指数；卵巢反应性；治疗结局; ; 

   

  Abstract: To investigate the predictive value of the ovarian sensitivity index (OSI) for ovarian response and clinical pregnancy rates in infertile patients undergoing in vitro fertilization-embryo transfer (IVF-ET). Methods A retrospective analysis was conducted on 170 infertile patients who underwent their first IVF-ET treatment at Beijing Obstetrics and Gynecology Hospital, Capital Medical University / Beijing Maternal and Child Health Care Hospital from June 2019 to December 2019. According to the pregnancy outcomes, they were divided into a pregnancy group (80 cases) and a non-pregnancy group (90 cases). Variables achieving statistical significance in univariate analysis were examined for multicollinearity, and multivariate logistic regression was subsequently performed to identify independent predictors of clinical pregnancy. Results Univariate analysis indicated that the pregnancy group had a significantly lower maternal age compared with the non-pregnancy group, whereas the levels of AFC, AMH, retrieved oocyte number, serum E? on the day of hCG trigger, and OSI were markedly higher in the pregnancy group (all P < 0.05). No multicollinearity was detected among the variables. Multivariate logistic regression showed that OSI independently influenced clinical pregnancy rate (OR = 0.72, 95% CI: 0.56–0.92, P = 0.008). Conclusion OSI may serve as a useful predictor of ovarian response and pregnancy outcomes in patients undergoing IVF-ET.

  Key words: ovarian sensitivity index; ovarian reactivity; reatment outcomes

  提交时间：2026-09-02

  版权声明：作者本人独立拥有该论文的版权，预印本系统仅拥有论文的永久保存权利。任何人未经允许不得重复使用。
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• 序号	提交日期	编号	操作
  1	2026-07-01	10.12201/bmr.202609.00004V1	下载

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