通讯作者: 朱巍立, 1554399905@qq.com

DOI：10.12201/bmr.202512.00070

Advances in Research on Ferroptosis Reversing Platinum Resistance in Ovarian Cancer

• 摘要：卵巢癌是最致命的妇科恶性肿瘤。据统计,卵巢癌的5年总生存率低于30%,大部分患者在发现时就已是晚期。目前基础的治疗策略为先行肿瘤细胞减灭术后进行化疗,化疗药通常为铂类和紫杉烷。由于卵巢癌治疗方式的局限性,即使起初疗效佳,在治疗过程中也常常表现出化疗耐药,尤其是对铂类药物的耐药,近70%的患者会在两年内复发。铂类药物作用的主要机制是与DNA以共价键结合阻止DNA复制,同时促进ROS的形成引起氧化应激反应损伤DNA,从而诱导细胞凋亡。铁死亡是一种非凋亡形式的细胞死亡方式,因此铁死亡似乎是一种肿瘤抑制机制。铁死亡的主要机制为铁代谢异常、脂质过氧化及GPX4抗氧化系统的抑制,研究证实能通过以上三种途径促进肿瘤细胞铁死亡从而逆转铂耐药。目前已有较多铁死亡诱导措施得到验证,铁死亡诱导剂如青蒿素及其衍生物在肿瘤治疗领域也被认为极具潜力,但距离实际应用仍有很长的路要走。我们需要进一步探索药物诱导铁死亡的具体机制,使患者受益最大化。

  关键词： 铁死亡; 卵巢癌; 铂耐药; 青蒿素; 肿瘤

   

  Abstract: Ovarian cancer is the most lethal gynaecological malignancy. According to statistics, the 5-year overall survival rate of ovarian cancer is less than 30%, and most patients are already at an advanced stage when they are discovered. The current basic treatment strategy is chemotherapy after pre-cytoreductive surgery, usually platinum and taxanes. Due to the limitations of ovarian cancer treatment, even if the initial response is good, chemotherapy resistance, especially to platinum drugs, is often shown during treatment, and nearly 70% of patients will relapse within two years. The main mechanism of action of platinum drugs is to covalently bond with DNA to prevent DNA replication, and at the same time promote the formation of ROS, causing oxidative stress to damage DNA, thereby inducing apoptosis. Ferroptosis is a non-apoptotic form of cell death, so ferroptosis appears to be a tumor suppressor mechanism. The main mechanisms of ferroptosis are abnormal iron metabolism, lipid peroxidation and inhibition of the GPX4 antioxidant system, which have been confirmed to promote ferroptosis in tumor cells and reverse platinum resistance through the above three pathways. At present, many ferroptosis inducing measures have been validated, and ferroptosis inducers such as artemisinin and its derivatives are also considered to have great potential in the field of tumor treatment, but there is still a long way to go before practical application. We need to further explore the specific mechanism of drug-induced ferroptosis to maximize the benefits for patients.

  Key words: Ferroptosis; Ovarian cancer; Platinum resistance; Artemisinin; Tumor

  提交时间：2025-12-26

  版权声明：作者本人独立拥有该论文的版权，预印本系统仅拥有论文的永久保存权利。任何人未经允许不得重复使用。
• html

• 图表

• 杨林, 杨扬. 自噬依赖性铁死亡在癌症中的研究进展. 2024. doi: 10.12201/bmr.202410.00029

  田梦娇, 张爱琴. 卵巢癌术后分型辨治经验. 2024. doi: 10.12201/bmr.202411.00016

  王国超, 金敏, 通信作者:金敏. 逆转细菌耐药性中药及其作用机制研究进展. 2025. doi: 10.12201/bmr.202503.00056

  聂心雨, 刘凌燕. 多囊卵巢综合征中的铁死亡和内质网应激及相关潜在治疗靶点. 2025. doi: 10.12201/bmr.202507.00042

  兰玲燕, 陈舒铃, 陈昀, 舒琦瑾. 基于数据挖掘探讨专利复方治疗卵巢癌用药规律. 2025. doi: 10.12201/bmr.202510.00008

  仝文宇, 张 武. 铁死亡在口腔疾病中的分子机制及治疗靶点研究. 2025. doi: 10.12201/bmr.202510.00005

  陶欣慧. 复发性卵巢癌患者自我调节疲劳现状及其与自我感受负担、社会支持的相关性分析. 2024. doi: 10.12201/bmr.202406.00033

  姚根武, 王彦伟, 郭琎祎, 李露露, 党文博, 宋爱琳. 单细胞测序技术在乳腺癌中的研究进展. 2024. doi: 10.12201/bmr.202407.00053

  王子婕, 张鑫众. 叶酸受体阳性循环肿瘤细胞与非小细胞肺癌发生发展的研究进展. 2025. doi: 10.12201/bmr.202506.00024

  徐婧秋, 赵瑞国, 周禄荣, 王宁▲. 基于“生气邪气皆本于阴阳” 与铁死亡探讨结直肠癌的发病机制与辨治思路. 2025. doi: 10.12201/bmr.202505.00043

• 序号	提交日期	编号	操作
  1	2025-11-18	10.12201/bmr.202512.00070V1	下载

• 公开评论  匿名评论  仅发给作者 提交评论