通讯作者: 杨志虹, 54021382@qq.com

DOI：10.12201/bmr.202601.00033

Complex network-based analysis of acupuncture point dispensing patterns in the treatment of diminished ovarian reserve and premature ovarian failure

• 摘要：目的：基于复杂网络分析方法，探讨针灸治疗卵巢储备功能下降（diminished ovarian reserve，DOR）及卵巢早衰（premature ovarian failure，POF）的腧穴配伍规律，以期为临床治疗提供参考。方法：系统检索中国知网、万方数据及PubMed等中英文数据库，筛选合格文献并提取腧穴处方，构建数据库。运用IBM SPSS Modeler 18.0与Gephi 0.9.2软件，进行关联规则分析与复杂网络建模。结果： 共纳入61篇文献，提取61条有效处方，涉及60个腧穴，总使用频次为550次，总使用频次550次，使用频次最高为关元穴。腧穴归经以任脉和膀胱经为主。特定穴中交会穴使用次数最多。关联规则分析显示，三阴交-关元组合支持度最高（86.89%）。复杂网络分析示，腧穴配伍网络具有小世界效应，其中以关元、三阴交等32个腧穴为核心节点。结论：针灸治疗DOR及POF核心腧穴以关元、三阴交、足三里相互配伍为主，强调交会穴等特定穴的应用及远近配穴原则，治法侧重于补肾益气、调理冲任、养血健脾。

  关键词： 复杂网络；卵巢储备功能下降；卵巢早衰；针灸；腧穴配伍；规律; ; 

   

  Abstract: Objective:To investigate the acupoint compatibility patterns in acupuncture treatment for diminished ovarian reserve (DOR) and premature ovarian failure (POF) using complex network analysis, aiming to provide references for clinical practice.Methods:Relevant studies were systematically retrieved from Chinese and English databases, including CNKI, Wanfang Data, and PubMed. Eligible literature was screened, and acupoint prescriptions were extracted to establish a database. Association rule analysis and complex network modeling were conducted using IBM SPSS Modeler 18.0 and Gephi 0.9.2 software.Results:A total of 61 studies were included, yielding 61 valid prescriptions involving 60 acupoints, with a total frequency of 550 applications. The most frequently used acupoint was Guanyuan (CV4). In terms of meridian distribution, the Conception Vessel (Ren Mai) and the Bladder Meridian were predominant. Among specific acupoint categories, crossing points were the most commonly employed. Association rule analysis revealed that the combination of Sanyinjiao (SP6) and Guanyuan (CV4) had the highest support (86.89%). Complex network analysis indicated that the acupoint compatibility network exhibited small-world characteristics, with 32 core nodes including Guanyuan (CV4) and Sanyinjiao (SP6).Conclusion: Acupuncture treatment for DOR and POF primarily emphasizes the compatibility of core acupoints such as Guanyuan (CV4), Sanyinjiao (SP6), and Zusanli (ST36). The application emphasizes the use of specific points, particularly crossing points, and follows the principle of combining local and distal point selection. The therapeutic approach focuses on tonifying kidney qi, regulating the Conception and Thoroughfare Vessels, and nourishing blood to strengthen the spleen.

  Key words: Complex network；diminished ovarian reserve；premature ovarian failure； Acupuncture; Acupoint allocation; Regularity

  提交时间：2026-01-12

  版权声明：作者本人独立拥有该论文的版权，预印本系统仅拥有论文的永久保存权利。任何人未经允许不得重复使用。
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• 序号	提交日期	编号	操作
  1	2025-12-04	10.12201/bmr.202601.00033V1	下载

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