通讯作者: 张巧, 864567563@qq.com

DOI：10.12201/bmr.202603.00018

The Predictive Value of Serum AMH and Basal Progesterone Levels on Pregnancy Outcomes in Infertile Patients Undergoing Their First IVF/ICSI-ET Cycle

• 摘要：目的 探究血清抗缪勒氏管激素(AMH)和基础孕酮(P)水平对不孕症患者首次体外受精/卵胞浆内单精子注射-胚胎移植(IVF/ICSI-ET)助孕妊娠结局的预测价值。方法 回顾性分析2024年10月至2025年10月在宜春市妇幼保健院首次行IVF/ICSI助孕治疗的172例不孕症患者的临床资料,根据助孕后是否临床妊娠分为妊娠成功组(n＝94)和妊娠失败组(n＝78),比较两组的一般临床资料,通过Spearman秩相关分析AMH和基础P的相关性,运用Logistic回归分析影响辅助生殖妊娠结局的因素,采用受试者工作特征(ROC)曲线评估AMH和基础P对妊娠结局的预测价值。结果 妊娠成功组AMH和基础P水平显著高于妊娠失败组(P＜0.05),年龄、不孕年限、不孕类型、体质量指数(BMI)、孕次、产次、基础雌二醇、基础黄体生成素、基础卵泡生成素、基础泌乳素、基础睾酮、促性腺激素(Gn)启动量、Gn总剂量、Gn总天数、扳机日雌二醇、扳机日黄体生成素、扳机日孕酮、受精方式、移植方式、促排方案、移植胚胎类型均无统计学差异(P＞0.05)；Spearman相关性分析显示AMH和基础P无相关性(ρ=0.030,P=0.704)；多因素Logistic回归分析显示AMH和基础P是妊娠结局的独立影响因素(OR＝1.170、2.642,P＜0.05)；AMH和基础P预测妊娠结局的曲线下面积(AUC)分别为0.608、0.597(P＜0.05),联合检测AUC为0.656(P＜0.05)。结论 血清AMH和基础P是不孕症患者首次IVF/ICSI-ET助孕妊娠结局的影响因素,可作为预测妊娠结局的参考指标。

  关键词： 不孕症; 体外受精-胚胎移植; 抗缪勒氏管激素; 基础孕酮; 妊娠结局

   

  Abstract: Objective: To investigate the predictive value of serum anti-Müllerian hormone (AMH) and basal progesterone (P) levels for pregnancy outcomes in infertile patients undergoing their first cycle of in vitro fertilization(IVF)/intracytoplasmic sperm injection(ICSI)-embryo transfer (ET). Methods: A retrospective cohort study was performed on clinical data of 172 infertile patients who received their first IVF/ICSI treatment at Yichun Maternal and Child Health Hospital from October 2024 to October 2025. Patients were stratified into the pregnancy success group (n = 94) and pregnancy failure group (n = 78) based on the achievement of clinical pregnancy post-assisted reproduction. Baseline clinical characteristics were compared between the two groups. Spearman correlation analysis was employed to examine the correlation between AMH and basal P. Multivariate binary Logistic regression was conducted to identify independent factors influencing pregnancy outcomes. Employing receiver operating characteristic (ROC) curves to assess the predictive value of AMH and basal P regarding pregnancy outcomes. Results: The pregnancy success group exhibited significantly higher levels of AMH and basal P than the pregnancy failure group (both P < 0.05). No statistically significant differences were observed between the two groups in terms of age, duration of infertility, type of infertility, body mass index (BMI), gravidity, parity, basal estradiol, basal luteinizing hormone, basal follicle-stimulating hormone, basal prolactin, basal testosterone, initial gonadotropin (Gn) dose, total Gn dose, total Gn administration days, estradiol on trigger day, luteinizing hormone on trigger day, progesterone on trigger day, fertilization method, embryo transfer mode, ovulation induction protocol, or type of transferred embryo (all P > 0.05). Spearman correlation analysis revealed no significant correlation between AMH and basal P (ρ = 0.030, P = 0.704). Multivariate Logistic regression model identified AMH and basal P levels as independent factors associated with pregnancy outcomes(OR = 1.170, 2.642; both P < 0.05). The area under the ROC curve (AUC) for AMH and basal P in predicting pregnancy outcomes was 0.608 and 0.597, respectively (both P < 0.05), while the combined detection yielded an AUC of 0.656 (P < 0.05). Conclusion: Serum AMH and basal P are independent influencing factors for pregnancy outcomes in infertile patients undergoing their first IVF/ICSI-ET cycle, and can serve as potential reference indicators for predicting pregnancy outcomes.

  Key words: Infertility; In vitro fertilization-embryo transfer; Anti-Müllerian hormone; Basal progesterone; Pregnancy outcome

  提交时间：2026-03-07

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• 序号	提交日期	编号	操作
  1	2026-01-22	10.12201/bmr.202603.00018V1	下载

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