Mechanisms of Dietary Inflammation Modulation in Improving Diabetic Retinopathy

Corresponding author: ZHAO YONG, 13999972362@163.cm

DOI: 10.12201/bmr.202507.00069

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  Abstract: Diabetic retinopathy , the most common microvascular complication of diabetes, has emerged as the leading cause of blindness among working-age populations. In recent years, the pivotal role of oxidative stress in the pathogenesis and progression of DR has gained increasing recognition. This review summarizes the pathological mechanisms of DR, with particular emphasis on the central position of oxidative stress; systematically examines the mechanisms of action of common antioxidants (such as vitamin C, vitamin E, α-lipoic acid, carotenoids, and polyphenolic compounds) and their research advancements in DR prevention and treatment; provides a detailed analysis of the molecular mechanisms through which antioxidants exert retinal protective effects by modulating redox homeostasis, suppressing inflammatory responses, and preserving vascular endothelial function; and offers perspectives on the potential applications and challenges of antioxidants in the clinical management of DR, thereby proposing novel strategies for DR prevention and treatment.

  Key words: Diabetic retinopathy ；Antioxidant therapy；Oxidative stress；ROS；Retinal protection；Diabetic microvascular complications; ; ; ; ; 

  Submit time: 25 July 2025

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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