Research Progress and Prospects of Finerenone in the Treatment of Diabetic Nephropathy

Corresponding author: Han Fei, hanf8876@zju.edu.cn

DOI: 10.12201/bmr.202410.00033

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  Abstract: Diabetic kidney disease (DKD) is one of the most common complications in diabetic patients and a leading cause of end-stage renal disease (ESRD). Oxidative stress plays a crucial role in the onset and progression of DKD, contributing to glomerular and tubular cell damage, inflammation, and fibrosis. In recent years, the mineralocorticoid receptor (MR) activation has been increasingly linked to oxidative stress, making it a promising therapeutic target for DKD. Finerenone, a novel non-steroidal mineralocorticoid receptor antagonist (MRA), has demonstrated significant anti-inflammatory, antifibrotic, and antioxidant effects by blocking MR activity. Clinical trials such as FIDELIO-DKD and FIGARO-DKD have shown that finerenone effectively slows kidney function decline in DKD patients and reduces cardiovascular events. However, identifying suitable biomarkers to assess finerenone’s effects on oxidative stress and kidney function improvement remains insufficiently explored, warranting further investigation. This review delves into the pathophysiological mechanisms of oxidative stress in DKD and highlights recent advances in understanding finerenones role in mitigating oxidative stress and safeguarding kidney function.

  Key words: Diabetic kidney disease; Oxidative stress; Finerenone; Mineralocorticoid receptor

  Submit time: 12 October 2024

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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