Application and research progress of molecular detection techniques in the diagnosis of childhood tuberculosis

Corresponding author: Yu Xin, xinxin810104@126.com

DOI: 10.12201/bmr.202506.00029

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  Abstract: Tuberculosis(TB) is a significant global public health issue, and the diagnosis of childhood tuberculosis faces many challenges. Molecular detection techniques, with their advantages of speed, high sensitivity, and high specificity, have been widely used in tuberculosis diagnosis. This paper reviews the application progress of various molecular detection techniques in the diagnosis of childhood tuberculosis, including nucleic acid amplification detection techniques, next-generation sequencing techniques, and linear probe techniques. By elaborating on the principles, characteristics, advantages, and the current application status and research progress of these techniques in the diagnosis of childhood tuberculosis, this paper aims to provide new ideas and methods for the diagnosis of childhood tuberculosis, with the expectation of improving the diagnosis rate of childhood tuberculosis and offering support for its early detection, timely treatment, and prevention.

  Key words: Tuberculosis; children; molecular detection techniques; diagnosis

  Submit time: 13 June 2025

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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  1	2025-05-14	bmr.202506.00029V1	Download

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