The Value of Intravenous Paracetamol Combined with Nerve Block in Preoperative Analgesia for Elderly Patients with Hip Fracture

Corresponding author: liyunwei, liyunwei2022@163.com

DOI: 10.12201/bmr.202501.00024

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  Abstract: 【Abstract】 Objective To evaluate the safety and efficacy of preoperative intravenous paracetamol, and to investigate the effect and influence on clinical prognosis of intravenous paracetamol combined with nerve block for preoperative analgesia in elderly patients with hip fracture. Methods Eighty elderly patients with hip fracture admitted to our hospital from December 2023 to August 2024 were selected as the research subjects, all patients were treated with 0.25% ropivacaine 20ml for pericapsular nerve group block(PENG block), and then they were randomly divided into intravenous paracetamol group and oral paracetamol group, acetaminophen was given once every 6h, 500mg each time, a total of 4 times, analgesic effects, adverse reactions, and short-term prognostic indicators were compared between the two groups. Results The pain relief time in the intravenous paracetamol group (10.05±2.89) was shorter than that in the oral group (23.63±8.10), and the rescue analgesic doses were fewer and the use of opioid drugs was lower in the intravenous group (0.60±1.45 and 1.80±2.21, respectively), (p<0.05). There were no significant differences in the incidence of adverse reactions, short-term prognostic indicators such as duration of hospital stay and improved discharge rate between the two groups (p>0.05). Conclusions Intravenous paracetamol combined with nerve block can be safely and effectively used for preoperative analgesia in elderly patients with hip fracture.

  Key words: Paracetamol, Elderly Hip Fracture, Preoperative Analgesia

  Submit time: 8 January 2025

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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