Exploring the role of MZT2A in skin cutaneous melanoma based on multiomics data

Corresponding author: lu lingyi, lulingyi802@foxmail.com

DOI: 10.12201/bmr.202412.00012

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  Abstract: Objective Based on multiomics data mining, we explored and evaluated the association between mitotic spindle organizing protein 2A (MZT2A) and survival prognosis and immunotherapy response of skin melanoma (SKCM). Methods The expression difference and survival prognosis of MZT2A in SKCM were analyzed by TCGA database, GTEX data, HPA, SUMMER database. The biological function of MZT2A and related enriched pathways were analyzed by David2. The differences of immune infiltrating cells, immune therapy response and immune escape ability between high- and low- MZT2A groups were analyzed and compared by using TIMER, TISCH, TISIDB, TCIA and TIDE databases..Results The expression of MZT2A gene is elevated in a variety of cancers, especially in SKCM. SKCM samples with high expression of MZT2A have a poor overall survival. The expression of MZT2A was negatively correlated with the infiltration of CD8+T cells, CD4+T cells, macrophages, neutrophils and dendritic cells in SKCM tissues. In addition, the higher the expression of MZT2A, the worse the therapeutic response of SKCM to immune checkpoint inhibitors.. Conclusion MZT2A is a novel survival prediction target of SKCM. SKCM patients with high expression of MZT2A have poor response to immune checkpoint inhibitor treatment, which provides a theoretical basis for predicting the survival prognosis o and guiding immune targeted therapy of SKCM.

  Key words: skin cutaneous melanoma; mitotic spindle organizing protein 2A (MZT2A); prognosis; multiomics; immunotherapy

  Submit time: 3 December 2024

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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