Circulating Tumor Cell HER-2 Expression in the Targeted Therapy of Gastric Adenocarcinoma

Corresponding author: Luoyushuang, 13897208152@163.com

DOI: 10.12201/bmr.202408.00001

•  

  Abstract: 【】Gastric cancer is one of the common malignancies in the digestive system. Currently, HER-2 (Human Epidermal Growth Factor Receptor 2) has been identified as an important molecular marker in the treatment of gastric adenocarcinoma. However, the heterogeneity and variability of tumors limit the evaluation of HER-2 by tissue biopsy. Circulating tumor cells (CTCs) shed from primary or metastatic lesions into the blood can reflect the molecular features of tumor cells. Studies have shown that HER-2 expression can be detected in CTCs of gastric adenocarcinoma patients, and CTC detection can dynamically monitor the expression status of HER-2, compensating for the limitations of single-point tissue sampling. Therefore, this article will review the predictive value of CTC-HER-2 detection in evaluating the efficacy of targeted therapy in gastric adenocarcinoma patients and the latest advancements in clinical research.

  Key words: Gastric Cancer; Circulating Tumor Cells (CTC); Human Epidermal Growth Factor Receptor 2 (HER-2); Prognosis

  Submit time: 1 August 2024

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
• html

• 图表

• Wang Yaoqiang, Wang Haohao, Luo Changjiang. The role of HMGB1 in the progression and therapy of Gastric Cancer. 2024. doi: 10.12201/bmr.202412.00009

  WangZhiyuan, Mengling, Shijuan, LiuYuanyuan, LiRuidi, LiWenxin, AnShuhong. Expression and the role of TFF3 in lung adenocarcinoma based on bioinformatics analysis. 2024. doi: 10.12201/bmr.202403.00019

  liushunlin. The expression of CPNE1 and ZWILCH in the progression of lung adenocarcinoma and their correlation with prognosis. 2024. doi: 10.12201/bmr.202406.00030

  YaQin Hao, YunFeng Hu, Jing Hao, Xin Zhao. Research of circular RNA and autophagy in gastric cancer. 2023. doi: 10.12201/bmr.202304.00001

  lin bingjiang, qiu xie, huang hua, xu suling, lu lingyi. Exploring the role of MZT2A in skin cutaneous melanoma based on multiomics data. 2024. doi: 10.12201/bmr.202412.00012

  Yao Genwu, Wang Yanwei, Guo Jinyi, Li Lulu, Dang Wenbo, Song Ailin. Advances in single-cell sequencing in the breast cancer. 2024. doi: 10.12201/bmr.202407.00053

  quyanli. Efficacy and safety of preoperative chemotherapy in real world patients with locally advanced gastric/gastroesophageal junction adenocarcinoma. 2024. doi: 10.12201/bmr.202409.00052

  HONG Liang, PAN Anna, WU Yanghe, YE Xiaoting. Esculin improve lipid accumulation in hepatocytes by inhibiting the PERK/eIF2A/ATF4 signaling pathway. 2024. doi: 10.12201/bmr.202409.00013

  ChenYu, libowen, yangjinhua, liuyang, weiyunwei. Research progress and prospect of targeted therapy of microflora in hepatocellular carcinoma. 2024. doi: 10.12201/bmr.202412.00033

  张楠, dujing. Research progress of O2O model in chronic disease management. 2024. doi: 10.12201/bmr.202407.00026

• ID	Submit time	Number	Download
  1	2024-07-05	bmr.202408.00001V1	Download

• Public  Anonymous  To author only Submit Comments