A Study on Mechanisms of Endoplasmic Reticulum Stress in Dry Eye Based on Theory of Fluid Imbalance

Corresponding author: pengqinghua, pqh41007@126.com

DOI: 10.12201/bmr.202607.00014

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  Abstract: Taking the theory of ‘fluid imbalance’ as a starting point, this study explores its correlation with endoplasmic reticulum (ER) stress mechanisms in the onset and progression of dry eye. It posits that disruption of ER homeostasis is a key prerequisite for fluid imbalance, with impaired protein folding and secretion serving as its specific manifestations; inflammatory responses and oxidative stress constitute the key pathological processes; and insufficient lubrication of the eye represents the ultimate clinical manifestation. Elucidating the implications of fluid imbalance at the level of microscopic molecular mechanisms provides a theoretical basis for understanding the pathogenesis of dry eye from the perspective of ‘fluid imbalance’ and for identifying targets for Traditional Chinese Medicine intervention.

  Key words: dry eye; fluid imbalance; endoplasmic reticulum stress; protein misfolding; inflammatory response

  Submit time: 7 July 2026

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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  1	2026-06-28	10.12201/bmr.202607.00014V1	Download

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