Efficacy of Different Frequencies of Transcutaneous Electrical Nerve Stimulation Combined with Sodium Hyaluronate Eye Drops in the Treatment of Dry Eye Syndrome

Corresponding author: Chang Wang, 1930830414@qq.com

DOI: 10.12201/bmr.202602.00045

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  Abstract: Abstract Objective To evaluate the clinical efficacy of transcutaneous electrical stimulation at different frequencies combined with sodium hyaluronate eye drops in patients with dry eye. Methods In this randomized controlled study, patients with dry eye who met the inclusion criteria were randomly assigned to a control group, a low-frequency group, a medium-frequency group, and a high-frequency group. The control group received sodium hyaluronate eye drops alone, while the other three groups received additional transcutaneous electrical stimulation at different frequencies for 4 weeks. Ocular surface disease index (OSDI), non-invasive tear breakup time (NITBUT), Schirmer I test (SIT), and numeric rating scale (NRS) scores were assessed at baseline, 2 weeks, and 4 weeks. Repeated-measures analysis of variance was used to compare changes over time among the groups. Results Repeated-measures analysis of variance showed significant time effects for OSDI, NITBUT, SIT, and NRS in all groups (P<0.001). Significant time × group interaction effects were observed for NITBUT, SIT, and NRS (P<0.05), indicating differences in improvement trends among the treatment groups. At the 4-week endpoint, the high-frequency group demonstrated significantly greater improvements in tear film stability, tear secretion, and ocular pain relief compared with the control group (P<0.001). Conclusion Transcutaneous electrical stimulation combined with sodium hyaluronate eye drops can significantly improve both subjective symptoms and objective signs in patients with dry eye. Relatively higher-frequency stimulation shows certain clinical advantages in improving tear film stability, tear secretion, and ocular pain.

  Key words: Dry eye disease; Transcutaneous electrical stimulation; Sodium hyaluronate; Ocular Surface Disease Index; Randomized controlled study

  Submit time: 11 February 2026

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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  1	2026-01-19	10.12201/bmr.202602.00045V1	Download

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