通讯作者: 王畅, 1930830414@qq.com

DOI：10.12201/bmr.202602.00045

Efficacy of Different Frequencies of Transcutaneous Electrical Nerve Stimulation Combined with Sodium Hyaluronate Eye Drops in the Treatment of Dry Eye Syndrome

• 摘要：摘要 目的 评价不同频率经皮电刺激联合透明质酸钠滴眼液对干眼患者临床疗效。方法 采用随机对照研究设计，将符合纳入标准的干眼患者随机分为对照组、低频组、中频组和高频组。对照组给予透明质酸钠滴眼液治疗，其余三组在此基础上联合不同频率经皮电刺激治疗，连续干预4周。分别于治疗前（基线）、治疗2周及4周评估4组眼表疾病指数（ocular surface disease index，OSDI）、非接触式泪膜破裂时间（non-invasive tear breakup time，NITBUT）、泪液分泌试验（Schirmer I test，SIT）及眼部疼痛评分（numeric rating scale，NRS）。采用重复测量方差分析比较各组随时间的变化情况。结果 重复测量方差分析结果显示，各组OSDI、NITBUT、SIT及NRS评分均存在显著时间主效应（P＜0.001）。在NITBUT、SIT及NRS指标中，时间×组别交互效应具有统计学意义（P＜0.05），提示不同治疗方案的改善趋势存在差异。4周终点时，高频组在改善泪膜稳定性、泪液分泌及缓解眼部疼痛方面均优于对照组（P＜0.001）。结论 经皮电刺激联合透明质酸钠滴眼液可明显改善干眼患者的主观症状及客观体征，其中相对较高频率的经皮电刺激在改善泪膜稳定性、泪液分泌及眼部疼痛方面显示出一定的临床优势。

  关键词： 干眼；经皮电刺激；透明质酸钠；眼表疾病指数；随机对照研究; ; ; ; 

   

  Abstract: Abstract Objective To evaluate the clinical efficacy of transcutaneous electrical stimulation at different frequencies combined with sodium hyaluronate eye drops in patients with dry eye. Methods In this randomized controlled study, patients with dry eye who met the inclusion criteria were randomly assigned to a control group, a low-frequency group, a medium-frequency group, and a high-frequency group. The control group received sodium hyaluronate eye drops alone, while the other three groups received additional transcutaneous electrical stimulation at different frequencies for 4 weeks. Ocular surface disease index (OSDI), non-invasive tear breakup time (NITBUT), Schirmer I test (SIT), and numeric rating scale (NRS) scores were assessed at baseline, 2 weeks, and 4 weeks. Repeated-measures analysis of variance was used to compare changes over time among the groups. Results Repeated-measures analysis of variance showed significant time effects for OSDI, NITBUT, SIT, and NRS in all groups (P<0.001). Significant time × group interaction effects were observed for NITBUT, SIT, and NRS (P<0.05), indicating differences in improvement trends among the treatment groups. At the 4-week endpoint, the high-frequency group demonstrated significantly greater improvements in tear film stability, tear secretion, and ocular pain relief compared with the control group (P<0.001). Conclusion Transcutaneous electrical stimulation combined with sodium hyaluronate eye drops can significantly improve both subjective symptoms and objective signs in patients with dry eye. Relatively higher-frequency stimulation shows certain clinical advantages in improving tear film stability, tear secretion, and ocular pain.

  Key words: Dry eye disease; Transcutaneous electrical stimulation; Sodium hyaluronate; Ocular Surface Disease Index; Randomized controlled study

  提交时间：2026-02-11

  版权声明：作者本人独立拥有该论文的版权，预印本系统仅拥有论文的永久保存权利。任何人未经允许不得重复使用。
• html

• 图表

• 沈颖. 红光联合神经肌肉电刺激对全膝关节置换术后患者康复效果的影响. 2025. doi: 10.12201/bmr.202511.00073

  彭新, 龙茜, 侯宛君, 彭俊, 彭清华. 基于津液失调理论下的干眼内质网应激机制探讨. 2026. doi: 10.12201/bmr.202607.00014

  姚益清, 文庭孝, 丘奂阳. 眼动生理特征及应用研究综述. 2024. doi: 10.12201/bmr.202412.00079

  郑秀丽. 重复经颅磁刺激治疗功能性便秘的临床疗效观察. 2025. doi: 10.12201/bmr.202511.00010

  马小言, 杨鹏, 郭颖, 付滨. Klotho蛋白的抗氧化应激与年龄相关性眼病. 2025. doi: 10.12201/bmr.202501.00021

  作者:杜昊澎, 吴子祥, 王小兵. AI智能反馈系统联合模拟内镜培训与无反馈模拟培训在胃镜操作技能提升中的随机对照研究. 2026. doi: 10.12201/bmr.202605.00104

  李威威, 王保功. 阿齐沙坦氨氯地平与阿利沙坦酯氨氯地平治疗原发性高血压的8周随机对照研究：4周中期疗效分析. 2026. doi: 10.12201/bmr.202606.00006

  夏晓霏, 陈向东, 蔡玲. 基于“脾胃虚则九窍不通”探讨从脾胃治疗脂质异常型干眼. 2025. doi: 10.12201/bmr.202511.00085

  梁春兰, 师齐, 刘莲, 钟敬祥. 间充质干细胞来源的外泌体与眼免疫性疾病. 2022. doi: 10.12201/bmr.202209.00019

  王可欣, 张少强. 不同功效组合的中药复方联合常规西药治疗冠心病合并抑郁的网状Meta 分析. 2024. doi: 10.12201/bmr.202410.00055

• 序号	提交日期	编号	操作
  1	2026-01-19	10.12201/bmr.202602.00045V1	下载

• 公开评论  匿名评论  仅发给作者 提交评论