Research Progress on Risk Factors and Treatment Strategies for Multifocal Anogenital Intraepithelial Neoplasia in Women

Corresponding author: CHANG Shufang, shfch2005@163.com

DOI: 10.12201/bmr.202604.00140

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  Abstract: Multizonal anogenital intraepithelial neoplasia(MZIN) is a clinically significant yet often overlooked special type of HPV-related precancerous lesion affecting the lower genital tract and anus. Its development is associated with multiple factors, including persistent infection with high-risk HPV, abnormal host immune status, a history of high-grade lesions, and imbalance of the local microenvironment. Because current screening and diagnostic strategies are largely focused on single-site lesions, MZIN still presents major clinical challenges, such as a high rate of missed diagnosis, lack of standardized treatment pathways, and a high risk of recurrence. Comprehensive regional assessment for high-risk populations, strengthened multidisciplinary collaboration, individualized treatment strategies based on lesion grade and involved sites, and standardized long-term follow-up are key to improving the diagnosis and management of MZIN.

  Key words: Multizonal anogenital intraepithelial neoplasia; Human papillomavirus; Risk factors; Diagnosis; Treatment

  Submit time: 21 April 2026

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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  1	2026-03-29	10.12201/bmr.202604.00140V1	Download

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