Analysis of the Distribution of High-risk Human Papillomavirus Subtypes and High-risk Factors among Women in Jiaxing, Zhejiang Province

DOI: 10.12201/bmr.202502.00011

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  Abstract: Objective To investigate the distribution of high-risk human papillomavirus (HR-HPV) subtypes and risk factors in local area, so as to provide reference for cervical cancer screening in high-risk population. Methods A total of 22573 women from Zhejiang Cervical Cancer screening project management system were selected for HR-HPV screening, and they were divided into HR-HPV positive group (2045 cases) and negative group (20528 cases). The medical history data of the patients were analyzed, and the risk factors of HR-HPV infection were analyzed by univariate and multivariate regression analysis. Results The overall HR-HPV infection rate was 9%. HPV52 was the most common type in single infection (29.6%), and HPV2 was the most common type in multiple infections (13%). There were significant differences between HR-HPV positive group and negative group in age, education level, gravidity, number of abortions and different neighborhoods (P < 0.05). Multivariate Logistic regression analysis showed that age >45 years old, primary school education or above, twice pregnancy were independent risk factors for HR-HPV infection. Conclusions: HPV52 is the predominant type of HR-HPV in the local area. Age >45 years, education level above primary school, and twice pregnancy are related risk factors for HR-HPV infection.

  Key words: High-risk human papillomavirus (HR-HPV); Screening; Age; Education background; Risk Factors

  Submit time: 10 February 2025

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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