Discussion on the Etiology, Pathogenesis, Prevention and Treatment of Persistent High-Risk HPV Infection Based on “Latent Pathogen” Theory

Corresponding author: Wang Lingli, WLL19791011@163.com

DOI: 10.12201/bmr.202510.00027

•  

  Abstract: Persistent infection with high-risk human papillomavirus (HR-HPV) has emerged as a prominent concern in the field of cervical lesions in recent years. To deepen the understanding of its pathological essence and expand clinical diagnostic and therapeutic approaches, this study explores the intrinsic association between persistent HR-HPV infection and the theory of latent pathogens in traditional Chinese medicine (TCM). Specifically, it integrates the latent pathogen theory with the core TCM pathogenesis of HR-HPV infection—characterized as dampness-toxin lurking in the uterine cavity and lingering pathogenic factors amid vital qi deficiency—to systematically elucidate its TCM pathological mechanisms. Building on this, the study proposes a therapeutic strategy of combining reinforcement and elimination, targeting the four key pathogenesis elements (dampness, heat, deficiency, and toxin). This strategy involves regulating and tonifying the liver, spleen, and kidney to strengthen vital qi while clearing away dampness, heat, and toxin to expel pathogens, thereby providing guidance for clinical practice.

  Key words: [keywords missed]

  Submit time: 16 October 2025

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
• html

• 图表

• LiMei, Lou Jiaoying. To study the efficacy and mechanism of Qingdu suppository in the treatment of high risk human papillomavirus (HR-HPV) persistent infection. 2024. doi: 10.12201/bmr.202412.00028

  李娟, Hou Zhonghao, Song Shanshan, Jia Weihao, Song Zixian, Niu Tianfu. Exploring the ideas of prevention and treatment of senile insomnia based on the theory of ambrosia and phlegm. 2024. doi: 10.12201/bmr.202410.00064

  Analysis of the Distribution of High-risk Human Papillomavirus Subtypes and High-risk Factors among Women in Jiaxing, Zhejiang Province. 2025. doi: 10.12201/bmr.202502.00011

  DAI Xin-zhen, LIAO Yan-ting, LUO Xiao-wan, FU Li-hua. LUO Yan-yan1, DAI Xin-zhen2, LIAO Yan-ting1, LUO Xiao-wan2, FU Li-hua1. 2024. doi: 10.12201/bmr.202410.00056

  WangZiyi, KeShiyan, LiuQiang. Exploring the Pathogenesis and Management Strategies of Presyncope from the Perspective of the ascending the Qing and descending the Zhuo Theory. 2025. doi: 10.12201/bmr.202505.00052

  xuwangbing, zhongfaming, liumin, xurui, yeyongxiang. Discussion on the TCM Diagnosis and Treatment Approach of Lumbar Disc Herniation with Sciatica Based on the Theory of Collaterals. 2025. doi: 10.12201/bmr.202504.00047

  Meiyu Yao. Discussion on the Pathogenesis and Prevention methods of Ectopic Pregnancy Based on Three-in-One View of Life of Form,Qi and Spirit. 2025. doi: 10.12201/bmr.202509.00051

  JIANG Shali. Research on the Expression of SLPI in Cervical Adenocarcinoma and Its Correlation with HPV Infection. 2025. doi: 10.12201/bmr.202505.00012

  Wang Yirong. Treatment of female stress urinary incontinence based on the theory of The lung governs the regulation of water pathways. 2025. doi: 10.12201/bmr.202506.00044

  Zou Di. Exploring the Association Between Tonsillar Infection and IgA Nephropathy Based on the Theory of the Throat-Kidney Axis. 2025. doi: 10.12201/bmr.202508.00043

• ID	Submit time	Number	Download
  1	2025-08-15	10.12201/bmr.202510.00027V1	Download

• Public  Anonymous  To author only Submit Comments