Clinical application study of GUI PI Mixture combined with iron sucrose and hemagase of White Eyebrow Snake venom for Injection in reducing perioperative blood loss during orthopetic surgery for senile degenerative scoliosis

DOI: 10.12201/bmr.202604.00002

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  Abstract: Objective: To explore the clinical effect of GUI PI Mixture combined with iron sucrose and hemocoagulase of white Eyebrow snake venom for injection on reducing perioperative blood loss in orthopetic surgery for senile degenerative scoliosis. Methods: From March 2023 to March 2025., 70 patients undergoing orthopedic surgery for senile degenerative scoliosis were included and randomly assigned to control group and observation group according to random number table method, with 35 cases in each group. Patients in control group received routine blood intervention for perioperative blood loss in elderly DS orthopedic patients, while patients in observation group were added with GUI PI Mixture on basis of control group. The differences in laboratory blood loss index levels, intraoperative blood loss, blood transfusion volume, blood transfusion rate, occurrence of postoperative adverse reactions, and postoperative spinal function were compared between two groups. Result: The tests at 24 hours and 7 days after operation showed that levels of RBC, HB and HCT in observation group were significantly higher than those in control group(P<0.05). Three indicators of intraoperative blood loss, blood transfusion volume and blood transfusion rate were all significantly lower than those of control group(P<0.05). There was no significant difference in incidence of adverse reactions between two groups after operation(P>0.05), but 1-month follow-up after operation showed that the improvement amplitudes of ODI and NRS scores in observation group were better than those in control group(P<0.05). Conclusion: GUI PI Mixture combined with iron sucrose and hemagglutinin from White Eyebrow snake venom for injection can reduce perioperative blood loss during orthopetic surgery for senile degenerative scoliosis and optimize postoperative spinal function.

  Key words: Degenerative scoliosis; Old age; Orthopedics; GUI PI Mixture; Blood loss

  Submit time: 1 April 2026

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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