Research progress on the role of helicobacter pylori infection in the development of Autoimmune diseases in the digestive system

Corresponding author: LUN Wei-jiang, lwj198407@163.com

DOI: 10.12201/bmr.202603.00091

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  Abstract: Helicobacter pylori (Hp) is one of the most common pathogens in the digestive system. Recent studies have revealed that Hp acts as an immunomodulator, participating in the pathogenesis of digestive system autoimmune diseases through multiple mechanisms including molecular mimicry, immune cell regulation, and modulation of gastrointestinal microbiota, with differential effects across various diseases. Eradication of Hp has positive implications for the clinical management of these patients, though individualized decision-making is required based on disease characteristics. This review systematically summarizes the distinct roles of Hp in the development and progression of autoimmune gastritis, inflammatory bowel disease, autoimmune liver disease, and autoimmune pancreatitis, aiming to provide new insights for the diagnosis and treatment of digestive system autoimmune diseases.

  Key words: Helicobacter pylori; Digestive system autoimmune diseases; Immunomodulator; Molecular mimicry; Immune cell regulation; Gastrointestinal microbiota

  Submit time: 20 March 2026

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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