Research progress on the role of protein ubiquitination in the occurrence and development of gastric cancer

Corresponding author: Jiyunxi, ji-yunxi@163.com

DOI: 10.12201/bmr.202601.00012

•  

  Abstract: Ubiquitin (UB) is a small protein present in most eukaryotic cells that tags and disassembles specific proteins through the ubiquitination complex chain reaction, a process that is an important post-translational modification. Gastric cancer (GC) has various pathogenic factors, and protein ubiquitination can regulate the stability, activity, interaction, cell signaling, receptor downregulation and gene transcription processes of gastric cancer by covalently binding small molecule ubiquitin proteins, thereby affecting the progression and prognosis of gastric cancer. At the same time, there are different sites in the ubiquitination composite chain reaction, which can be used as a target for gastric cancer treatment drugs. In this paper, we will review the research progress in the last five years on the role of protein ubiquitination modification in gastric cancer development.

  Key words: Gastric cancer; Protein ubiquitinatio; Ubiquitin-protease; Deubiquitinating enzymes

  Submit time: 6 January 2026

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
• html

• 图表

• Wang Yaoqiang, Wang Haohao, Luo Changjiang. The role of HMGB1 in the progression and therapy of Gastric Cancer. 2024. doi: 10.12201/bmr.202412.00009

  YaQin Hao, YunFeng Hu, Jing Hao, Xin Zhao. Research of circular RNA and autophagy in gastric cancer. 2023. doi: 10.12201/bmr.202304.00001

  Li Lingbing, Chen Xi. The Research Progress of Traditional Chinese Medicine Monomers in Precancerous Lesions of Gastric Cancer. 2025. doi: 10.12201/bmr.202511.00037

  haoxiaoying. Clinical Research Progress of Gastrin in Gastric Precancerous Lesion. 2025. doi: 10.12201/bmr.202502.00030

  YANG Jiaqi, CUI Yan. Advance in research on the prevention and treatment of gastric cancer by Traditional Chinese Medicine through modulation of programmed cell death. 2025. doi: 10.12201/bmr.202512.00063

  Zhang Xinzhong. Research progress on folate receptor positive circulating tumor cells and the occurrence and development of non-small cell lung cancer. 2025. doi: 10.12201/bmr.202506.00024

  Liyali. Research Progress on the Role of Cell Division Cycle Associated 4 (CDCA4) in Tumors. 2025. doi: 10.12201/bmr.202510.00004

  He Xiao Yuan, Ning Mei. Research Progress on the Relationship between Insulin Resistance and the Occurrence and Development of Colorectal Cancer and Intervention Measures Chen Yunxiu 1, He Xiaoyuan 1, Ning Mei 2*. 2026. doi: 10.12201/bmr.202601.00062

  shenzhouji, guofei. Research progress of histone modification and DNA methylation in diabetes nephropathy. 2024. doi: 10.12201/bmr.202407.00011

  yuguozheng. Research Advances in Metadherin (MTDH) in Breast Cancer. 2026. doi: 10.12201/bmr.202601.00039

• ID	Submit time	Number	Download
  1	2025-11-14	10.12201/bmr.202601.00012V1	Download

• Public  Anonymous  To author only Submit Comments