Effects of Multi-Target Alternating Transcranial Direct Current Stimulation Combined with Task-Oriented Training on Motor Function and Surface Electromyographic Activity in Children with Motor Developmental Delay

DOI: 10.12201/bmr.202603.00088

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  Abstract: Objective To explore the effects of multi-target alternating transcranial direct current stimulation (tDCS) combined with task-oriented training on motor function and surface electromyographic (sEMG) activity in children with motor developmental delay. Methods A total of 80 children with motor developmental delay admitted to Ganzhou Maternal and Child Health Hospital from January 2023 and February 2024 were selected and divided into a control group and an observation group using a random number table, with 40 cases in each group. The control group received task-oriented training alone, while the observation group received multi-target alternating tDCS combined with task-oriented training. The total clinical effective rate, scores on the Peabody developmental motor scales-2 (PDMS-2), Berg balance scale (BBS) scores, and the difference in root mean square (RMS) values of bilateral limb sEMG signals before and after treatment were compared between the two groups. Results The total effective rate in the observation group was significantly higher than that in the control group (85.00% vs 62.50%, P<0.05). After treatment, compared with the control group, the observation group showed increases of 3.27 points in the gross motor quotient, 4.76 points in the fine motor quotient, and 3.68 points in the total motor quotient of the PDMS-2, as well as a 2.44-point increase in the BBS score, with all differences being statistically significant (P<0.05). Additionally, the RMS differences of surface electromyography in the bilateral biceps brachii and triceps brachii decreased by 1.57 μV and 2.60 μV, respectively, while those in the bilateral hamstrings and quadriceps decreased by 0.83 μV and 0.68 μV, respectively, with all differences being statistically significant (P<0.05). Conclusion Multi-target alternating tDCS combined with task-oriented training can effectively improve motor function, balance ability, and surface electromyographic features in children with motor developmental delay, and enhance the symmetry of bilateral limb muscle activity.

  Key words: Multi-target alternating transcranial direct current stimulation; Task-oriented training; Motor developmental delay; Children; Motor function; Surface electromyography

  Submit time: 20 March 2026

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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