Value on thromboelastography and coagulation function indexes for the evaluation of intrahepatic cholestasis in pregnancy

Corresponding author: ai ling, 674079406@qq.com

DOI: 10.12201/bmr.202603.00046

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  Abstract: Objective. To investigate how thromboelastography (TEG) and coagulation function indexes change in gravida with intrahepatic cholestasis of pregnancy（ICP）in order to find effective indicators of ICP.Methods. From February 2023 to January 2024,76 pregnant women with ICP who delivered their babies in our hospital (Jiaxing Maternal and Child Health Care Hospital) （observation group ） and other 80 randomly selected healthy subjects (control group)were enrolled in the study. The thromboelastography and coagulation function indexes from two groups were compared. The correlation of thromboelastography and coagulation function indexes between the severity of ICP were analyzed in the way of Pearson correlation.Results. The levels of α Angle,maximum amplitude (MA) , fibrinogen (FIB) and D-dimer (D-D) in the observation group were higher than those in the control group.（P<0.05）The α Angle,MA value,FIB,D-D were positively correlative with the severity of ICP (P<0.05).Conclusion. The thromboelastography and coagulation function indexes examined on patients with ICP were obviously abnormal which can be used to help evaluate the severity of ICP.

  Key words: intrahepatic cholestasis of pregnancy thromboelastography Coagulation index

  Submit time: 12 March 2026

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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