The Latest Research Progress on Gestational Diabetes Mellitus and Gut Microbiota

DOI: 10.12201/bmr.202509.00071

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  Abstract: Gestational Diabetes Mellitus (GDM) is a common pregnancy complication. In recent years, the incidence of GDM in China has shown a significant upward trend, becoming a major health burden for mothers and children. However, the specific etiology and pathophysiological mechanisms of GDM remain unclear. Recently, the importance of gut microbiota and related metabolic molecules has become prominent. Studies have shown that the gut microbiota and related metabolic molecules of GDM patients are significantly different. Given that the metabolic pathways of gut microbiota and related metabolites have substantial impacts on inflammation, insulin signaling, glucose and lipid metabolism, etc., gut microbiota or its metabolites (such as short-chain fatty acids) may play an important role in the onset and progression of GDM. Nevertheless, research on the role of gut microbiota during pregnancy is still in its infancy. This article reviews the role and mechanism of gut microbiota and related metabolic molecules in GDM, providing a new target for GDM intervention.

  Key words: gestational diabetes mellitus; Gut Microbiota; LPS; SCFAs

  Submit time: 30 September 2025

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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  1	2025-09-22	10.12201/bmr.202509.00071V1	Download

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