Research progress on the correlation between CAR, NAR, PAR, CRP/IBIL and the activity of ulcerative colitis

Corresponding author: SU Shasha, 850426418@qq.com

DOI: 10.12201/bmr.202601.00094

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  Abstract: Ulcerative colitis (UC) is a chronic non-specific inflammatory bowel disease, and its incidence is increasing year by year. Currently, although colonoscopy is the main method for the diagnosis and disease assessment of UC, its invasiveness, operational complexity and high cost have limited its clinical application to a certain extent. In recent years, blood-based composite biomarkers such as the C-reactive protein-albumin ratio (CAR), neutrophil-albumin ratio (NAR), platelet-albumin ratio (PAR), and C-reactive protein-Indirect Bilirubin ratio (CRP/IBIL) have gradually become research hotspots in this field due to their convenience and potential clinical value. This article systematically reviews the research progress of the above indicators in the monitoring of UC activity, etc. It focuses on analyzing their correlations with clinical scoring systems and endoscopic scoring systems, and deeply explores their diagnostic efficacy, advantages, and limitations as non-invasive biomarkers, aiming to provide new ideas and tools for the management of UC.

  Key words: Ulcerative colitis; Disease activity; C-reactive protein-albumin ratio; Neutrophil-albumin ratio; Platelet-albumin ratio; C-reactive protein-Indirect Bilirubin ratio

  Submit time: 31 January 2026

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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