Prevention and Treatment of Ulcerative Colitis with the Intestinal Mucosal Barrier As Target Based on Theory of “Spleen Being the Defensive Organ of Zang-Fu Viscera”

Corresponding author: tanyanyan, 853556748@qq.com

DOI: 10.12201/bmr.202512.00009

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  Abstract: It is currently believed that the pathogenesis of ulcerative colitis (UC) is mainly related to the damage of the intestinal mucosal barrier, closely related to the impairment of the intestinal mucosal barrier, involving dysbiosis of the gut microbiota, disruption of tight junction structures, damage to intestinal epithelial cells, immune imbalance, and excessive release of pro-inflammatory factors. The Traditional Chinese Medicine theory of spleen being the defensive organ of zang-fu viscera is a highly generalized concept of the physiological functions of the spleen and stomach, emphasizing that its role in maintaining the bodys vital activities and defending against external pathogens. Spleen being the defensive organ of zang-fu viscera is the core of the disease mechanism. The intestinal mucosal barrier functionally corresponds to the theory of spleen being the defensive organ of zang-fu viscera and can be regarded as a concrete manifestation of it. Damage to the intestinal mucosal barrier is similar to spleen losing of guard. The treatment of UC follows the principle of fortifying the spleen and restoring the defend and clearing dampness and heat together with clearing heat and detoxifying,promoting blood circulation to remove blood stasis and yangyinheying, which can repair the damaged intestinal mucosa and improve the intestinal mucosal barrier function, so as to achieve the purpose of treating UC.

  Key words: ulcerativecolitis; spleen being the defensive organ of zang-fu viscera; spleen failing in its defensive function; intestinal mucosal barrier; fortifying spleen and invigorating qi

  Submit time: 2 December 2025

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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