通讯作者: 谭妍妍, 853556748@qq.com

DOI：10.12201/bmr.202512.00009

Prevention and Treatment of Ulcerative Colitis with the Intestinal Mucosal Barrier As Target Based on Theory of “Spleen Being the Defensive Organ of Zang-Fu Viscera”

• 摘要：溃疡性结肠炎(ulcerative colitis，UC)的发病与肠道黏膜屏障受损密切相关，涉及肠道菌群失调、紧密连接结构受破坏、肠上皮细胞受损、免疫失衡、促炎因子过度释放等环节。中医学“脾为之卫”理论是对脾胃生理功能的高度概括，强调脾胃具有维持人体的生命活动与防御外邪的作用,“脾虚失卫，湿热蕴结”为UC的主要病机。肠黏膜屏障在功能上与“脾为之卫”理论具有相通之处，可视为“脾为之卫”的具体体现，肠黏膜屏障受损与脾失之卫的病变过程相似。因此，临证治疗上以肠道黏膜屏障为靶点，以“健脾复卫，清热利湿”为基本治疗原则，结合清热解毒、散瘀通络、养阴和营等法，使脾为之卫功能复常，肠黏膜屏障正常发挥防御作用，从而防治UC。

  关键词： 溃疡性结肠炎; 脾为之卫; 脾失之卫; 肠道黏膜屏障; 健脾复卫

   

  Abstract: It is currently believed that the pathogenesis of ulcerative colitis (UC) is mainly related to the damage of the intestinal mucosal barrier, closely related to the impairment of the intestinal mucosal barrier, involving dysbiosis of the gut microbiota, disruption of tight junction structures, damage to intestinal epithelial cells, immune imbalance, and excessive release of pro-inflammatory factors. The Traditional Chinese Medicine theory of spleen being the defensive organ of zang-fu viscera is a highly generalized concept of the physiological functions of the spleen and stomach, emphasizing that its role in maintaining the bodys vital activities and defending against external pathogens. Spleen being the defensive organ of zang-fu viscera is the core of the disease mechanism. The intestinal mucosal barrier functionally corresponds to the theory of spleen being the defensive organ of zang-fu viscera and can be regarded as a concrete manifestation of it. Damage to the intestinal mucosal barrier is similar to spleen losing of guard. The treatment of UC follows the principle of fortifying the spleen and restoring the defend and clearing dampness and heat together with clearing heat and detoxifying,promoting blood circulation to remove blood stasis and yangyinheying, which can repair the damaged intestinal mucosa and improve the intestinal mucosal barrier function, so as to achieve the purpose of treating UC.

  Key words: ulcerativecolitis; spleen being the defensive organ of zang-fu viscera; spleen failing in its defensive function; intestinal mucosal barrier; fortifying spleen and invigorating qi

  提交时间：2025-12-02

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• 序号	提交日期	编号	操作
  1	2025-10-23	10.12201/bmr.202512.00009V1	下载

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