通讯作者: 黄现会△, 18685036490@163.com

DOI：10.12201/bmr.202509.00025

A randomized controlled trial of Jiaoyu RS3 resistant starch in the treatment with atherosclerotic cerebral infarction in convalescent period

• 摘要：目的 探讨蕉芋RS3型抗性淀粉（Ce-RS3）对动脉粥样硬化性脑梗死患者恢复期血清中同型半胱氨酸（Hcy）水平及临床疗效观察。方法 本研究在贵州中医药大学第一附属医院神经内科进行，研究对象为2023年10月至2024年10月期间入院的60例处于脑梗死恢复阶段的患者，通过随机数字表法分为观察组与对照组，各30例。最终有观察组28例，对照组27例患者完成研究，共有55名参与者成功完成了该试验。对照组给予阿托伐他汀钙磷和阿司匹林，观察组给予阿托伐他汀钙磷、阿司匹林、蕉芋RS3型抗性淀粉治疗。治疗12周后，比较两组的血中Hcy水平、颈动脉斑块大小、美国国立卫生研究院卒中量表（NIHSS）、Barthel指数（BI）、中医症候积分变化情况。结果 治疗后，两组患者的血清Hcy水平均下降、颈动脉斑块均减小，NIHSS评分和中医证候积分均降低，观察组低于对照组（p<0.05）。治疗后，BI均升高，观察组高于对照组（p<0.05）。结论 Ce-RS3治疗动脉粥样硬化性脑梗死恢复期，有助于稳定动脉粥样硬化斑块，降低Hcy水平，从而改善患者神经功能，提升治疗有效率。

  关键词： 蕉芋RS3型抗性淀粉; 动脉粥样硬化性脑梗死; 恢复期; 同型半胱氨酸; 中医证候

   

  Abstract: Objective: Investigation of effect of the characteristic RS3 resistant starch from banana taro (Ce-RS3) on serum homocysteine (Hcy) level in patients with atherosclerotic cerebral infarction (ACI) during the recovery period. Methods: This study was conducted in the Department of Neurology at the First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine. The subjects were 60 patients in the convalescent phase of cerebral infarction who were admitted between October 2023 and October 2024. They were divided into an observation group and a control group, each comprising 30 patients, using a computer-generated random sequence. Finally, 28 patients in the observation group and 27 patients in the control group completed the study, with a total of 55 participants successfully finishing the trial. The control group was treated with Atorvastatin Calcium and Aspirin, while the observation group was treated with Atorvastatin Calcium, Aspirin, and Ce-RS3. After 12 weeks of treatment, the levels of Hcy in the blood, carotid artery plaque size, National Institutes of Health Stroke Scale (NIHSS), Barthel Index (BI), and changes in Traditional Chinese Medicine (TCM) symptom scores were compared between the two groups. Results: After treatment, the serum Hcy levels decreased and carotid plaque size was reduced in both groups, with the NIHSS scores and TCM syndrome scores also decreased, and the observation group was lower than the control group (p<0.05). After treatment, the BI increased, with the observation group higher than the control group (p<0.05). Conclusion: The results of this study show that Ce-RS3 has a significant effect on stabilizing atherosclerotic plaques and reducing serum Hcy levels, which is helpful to improve the neurological status and treatment efficacy.

  Key words: banana taro RS3 resistant starch; Atherosclerotic?cerebral?infarction; convalescent period; Homocysteine; TCM syndrome.

  提交时间：2025-09-09

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• 序号	提交日期	编号	操作
  1	2025-08-24	bmr.202509.00025V1	下载

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