通讯作者: 杨林, yanglin001517@163.com

DOI：10.12201/bmr.202409.00001

A Study on the Prediction of Acute Coronary Syndrome Based on Coronary Fat Attenuation Index and Laboratory Indicators

• 摘要：目的 探讨冠状动脉周围脂肪衰减指数（fat attenuation index ,FAI）联合实验室指标预测冠状动脉粥样硬化性心脏病(coronary heart disease, CHD)患者发生急性冠状动脉综合征(acute coronary syndrome ,ACS)风险的价值。方法 回顾性分析2015至2020年期间于本院确诊为CHD的患者，将其分为稳定性冠心病组（stable coronary artery disease ,SCAD组）、ACS组。SCAD组共纳入患者233例，ACS组221例。采用单因素及多因素Logistic回归分析冠状动脉主要分支右冠状动脉（right coronary artery , RCA）、左前降支（left anterior descending branch , LAD）及左旋支（left circumflex branch ,LCX）的FAI值、实验室指标及临床资料，筛选CHD患者发生ACS的独立影响因素；构建受试者工作特征(receiver operating characteristic ,ROC)曲线，并计算曲线下面积(area under the curve , AUC)，评价独立影响因素及其联合应用的预测效能。 结果 LAD-FAI、RCA-FAI及高敏C反应蛋白（high-sensitivity C-reactive protein , hs-CRP）是CHD患者发生ACS的独立影响因素。LAD-FAI、RCA-FAI、hs-CRP值升高单独预测CHD患者发生ACS的AUC分别为0.568、0.703、0.749，三者联合分析AUC为0.815。结论 LAD-FAI、RCA-FAI与hs-CRP联合分析对CHD患者发生ACS的风险具有较好的预测效能。

  关键词： 冠状动脉血管成像; 冠状动脉粥样硬化性心脏病 急性冠状动脉综合征; 血管周围脂肪衰减指数; 

   

  Abstract: Objective To explore the value of coronary fat attenuation index（FAI） combined with laboratory indicators in predicting the risk of acute coronary syndrome（ACS）in patients with coronary heart disease (CHD). Methods A retrospective analysis was conducted on patients who were diagnosed with CHD in our hospital from 2015 to 2020, these patients were divided into a stable coronary artery disease (SCAD) group and an acute coronary syndrome (ACS) group. Univariate and multivariate Logistic regression analyses were performed on the FAI values of the main coronary branches right coronary artery (RCA), left anterior descending branch (LAD), and left circumflex branch (LCX), laboratory indicators, and clinical data, to identify independent risk factors for ACS in CHD patients. Receiver operating characteristic (ROC) curves were constructed, and the area under the curve (AUC) was calculated to evaluate the predictive performance of the independent risk factors and their combinations. Results LAD-FAI, RCA-FAI, and high-sensitivity C-reactive protein (hs-CRP) are independent influencing factors for ACS in CHD patients. The AUCs for the prediction of ACS occurrence in CHD patients based on LAD-FAI, RCA-FAI, and elevated hs-CRP values alone are 0.568, 0.703, and 0.749, respectively. When these three factors are analyzed in combination, the AUC is 0.815.Conclusion The combined analysis of LAD-FAI, RCA-FAI, and hs-CRP has good predictive performance for assessing the risk of ACS in CHD patients.

  Key words: Coronary computed tomography angiography; Coronary heart disease; Acute coronary syndrome; fat attenuation index

  提交时间：2024-09-02

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• 序号	提交日期	编号	操作
  1	2024-08-16	bmr.202409.00001V1	下载

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