通讯作者: 吴苏龙, 742712769@qq.com

DOI：10.12201/bmr.202410.00060

Relationship of Human Neutrophil Peptides with the severity and prognosis of Acute Respiratory Distress Syndrome

• 摘要：目的 探讨人中性粒细胞多肽(HNPs)对急性呼吸窘迫综合征(ARDS)患者的病情严重程度及预后的评估作用。方法 选择2021年12月至2023年12月收住前海蛇口自贸区医院重症医学科的ARDS患者80例,在入住ICU24小时内留取患者血浆标本,采用ELISA方法检测血浆HNPs浓度。根据ARDS患者28天存亡情况分为存活组(48例)和死亡组(32例),比较两组患者的HNPs浓度和APACHE II分值等临床指标参数；采用Spearman相关性分析血浆HNPs浓度与APACHE II分值等指标的相关性；通过单因素logistic回归分析影响ARDS患者死亡的危险因素,对有统计学意义的危险因素再用多因素logistic回归模型分析死亡优势比(OR)。结果 ARDS患者28天死亡组的HNPs浓度、APACHE II分值均高于28天生存组,两组比较差异有统计学意义(p<0.05)；HNPs浓度与APACHE II分值呈正相关(r=0.344,p<0.05)；HNPs是影响ARDS患者28天预后的独立危险因素。结论 ARDS患者的血浆HNPs可用于ARDS患者病情危重程度和预后的早期评估。

  关键词： 急性呼吸窘迫综合征; 人中性粒细胞多肽; 急性生理学和慢性健康状况评分; 预后

   

  Abstract: Objective To investigate the relationship of human neutrophil peptides(HNPs) with the severity and prognosis in acute respiratory distress syndrome(ARDS) patients. Methods From December 2021 to December 2023, 80 ARDS patients were enrolled in the study. Plasma samples were taken within 24h after admission to ICU, HNPs concentration was then measured with enzyme-linked immune sorbent assay(ELISA). Differences in HNPs concentration and APACHE II score were compared in survival group (n=48) and non-survival group (n=32) based on their 28-days outcomes. The correlation between HNPs concentration and APACHE II score were calculatedbySpearman correlation analysis. Prognostic factors of 28-day-mortaliy were analyzed and the early predictors of most sensitive prognostic factor were explored by Multivariate logistic regression analysis. Results For ARDS patients 28-days outcome, HNPs concentration and APACHE II score of non-survival group was significantly increased than survival group(p<0.05). HNPs concentration has a positive correlation with APACHE II score(r=0.344, p<0.05). HNPs was an independent prognosis factor of 28-day mortality of ARDS patients. Conclusion Plasma HNPs concentration may be early used to evaluate the severity and prognosis of ARDS patients.

  Key words: ARDS; Human neutrophil peptides(HNPs); APACHE II score; Prognosis

  提交时间：2024-10-21

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• 序号	提交日期	编号	操作
  1	2024-09-16	bmr.202410.00060V1	下载

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