通讯作者: 文天才

DOI：10.12201/bmr.202404.00034

基于改进关联规则与Logistic回归算法集成的2型糖尿病中医证型鉴别研究

• 摘要：目的：分析2型糖尿病患者中西医特征间的多维交互关系及其对中医辩证的影响。方法：基于真实世界电子病历数据，改进传统关联规则算法，增加尊重度指标筛选出重要的中医证型作为因变量进入Logistic回归算法，分析中西医临床指标与中医证型的关联。结果：本研究共纳入T2DM患者688例，其中气阴两虚证317例，中土雍滞证186例，肝郁气滞证111例，肠道湿热证74例。最终得到关联规则112条，其中包含中医证型的有12条。中土雍滞证与超重/肥胖的关联规则尊重度最大(Respect=0.52)，且超重/肥胖患者的中土雍滞证患病率更高（OR=3.097,P<0.001）。中土雍滞证、合并周围神经病变或合并高血压与超重/肥胖的关联较强(Respect=0.42)。合并糖尿病肾病患者出现气阴两虚证的可能性更大（OR=1.475,P=0.019）。

  关键词： 2型糖尿病; 中西医特征; 中医证型; 关联规则; 真实世界研究

   

  Abstract: Objective: To analyze the multidimensional interaction between the characteristics of Chinese and Western medicine in patients with type 2 diabetes mellitus and its influence on TCM(Traditional Chinese Medicine) dialectics. Methods: Based on the real-world electronic medical record data,The traditional association rule algorithm is improved, and the important TCM syndromes are screened out as dependent variables by increasing respect index, and then the Logistic regression algorithm is used to explore the influence of Chinese and Western medicine indexes on TCM syndromes. Results: A total of 688 patients with T2DM were included in this study, including 317 cases of qi and yin deficiency syndrome, 186 cases of middle-earth stagnation syndrome, 111 cases of liver qi stagnation syndrome and 74 cases of intestinal damp-heat syndrome. Finally, 112 association rules are obtained, among which 12 rules contain TCM syndromes. The association rules between middle-earth stagnation syndrome and overweight/obesity has the greatest respect (Respect=0.52), moreover, overweight/obese patients have a higher prevalence rate of middle-earth stagnation syndrome (OR=3.097,P<0.001). There is a strong correlation between middle-earth stagnation syndrome 、peripheral neuropathy or hypertension with overweight/obesity (Respect=0.42). Patients with diabetic nephropathy are more likely to have qi and yin deficiency syndrome (OR=1.475,P=0.019).

  Key words: type 2 diabetes mellitus; Characteristics of Chinese and western medicine; TCM syndrome types; Association rules; Real world research

  提交时间：2024-04-26

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• 序号	提交日期	编号	操作
  1	2023-12-28	bmr.202404.00034V1	下载

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