通讯作者: 赵成玉, 414812019@qq.com

DOI：10.12201/bmr.202408.00019

Research Progress on the Relationship between Hyperuricemia and Diabetic Peripheral Neuropathy

• 摘要：当前,全球范围内高尿酸血症(HUA)及痛风患者人数呈逐年增长态势,在我国,高尿酸血症(HUA)已成为与“三高”并列的“第四高”疾病,发病数仅次于糖尿病。2型糖尿病(T2DM)常以其与其伴发的多种并发症威胁人体健康,其中糖尿病周围神经病变(DPN)为常见类型之一,相关数据统计,仅2022年全球DPN患病率达30%～70%。DPN常以感觉异常、四肢末端麻木及痛觉敏化为临床表现,是糖尿病足、糖尿病性溃疡、坏疽甚至截肢的重要原因。血清尿酸水平与血管功能障碍及血管不可逆损伤有关,可导致组织缺血和周围神经功能受损。目前对血清尿酸水平与糖尿病周围神经病变发生的关联性研究中尚无一致性观点,本文就近几年对二者关联性的相关研究进展进行综述。

  关键词： 糖尿病周围神经病变; 尿酸; 2型糖尿病

   

  Abstract: 【s】 The prevalence of patients with hyperuricemia (HUA) and gout is on the rise worldwide. In China, HUA has become a significant health concern, ranking alongside three other major diseases: hypertension, diabetes, and cardiovascular disease. Type 2 diabetes mellitus (T2DM) is a complex condition associated with numerous complications. Among these, diabetic peripheral neuropathy (DPN) is a particularly concerning issue.Type 2 diabetes mellitus (T2DM) frequently endangers human health through the complications it can cause. One such complication is diabetic peripheral neuropathy (DPN), which is estimated to affect between 30% and 70% of the global population by 2022. DPN is characterised by sensory abnormalities, numbness of the extremities and nociceptive sensitisation. It is the most significant contributor to diabetic foot, diabetic ulcers, gangrene and even limb amputation. DPN represents a significant risk factor for diabetic foot, diabetic ulcer, gangrene and even amputation. Elevated serum uric acid levels have been linked to vascular dysfunction and irreversible vascular damage, which can result in tissue ischemia and impaired peripheral nerve function. The current state of knowledge regarding the association between serum uric acid levels and the development of diabetic peripheral neuropathy is characterised by a lack of consensus. This article presents a summary of the research conducted over the past five years on this topic.

  Key words: ; ; 

  提交时间：2024-08-11

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• 序号	提交日期	编号	操作
  1	2024-08-07	bmr.202408.00019V1	下载

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