通讯作者: 许扬坡, 957829492@qq.com

DOI：10.12201/bmr.202608.00041

• 摘要：【】目的:观察自拟加味参苓白术散治疗COPD稳定期肺脾气虚型患者的临床效果。方法:将2024年7月至2025年7月在龙岩市中医院治疗的220例COPD稳定期肺脾气虚型患者随机分为对照组(110例)和观察组(110例)。两组均以常规西药维持治疗。对照组采用安慰剂,观察组予以自拟加味参苓白术散中药颗粒服用。两组治疗共12周,以12周为一疗程,共观察一个疗程。在治疗前后分别观察两组患者慢阻肺评估测试评分(CAT)、6分钟步行试验(6MWT)、血气分析及中医证候评分,并评定临床疗效。结果:治疗后,观察组临床总有效率高于对照组【92.73%(102/110)比80.00%(88/110),P＜0.05】；两组患者CAT评分和中医证候评分均较治疗前降低(P均＜0.05),且观察组低于对照组(P均＜0.05)；两组患者6MWT较治疗前升高(P＜0.05),且观察组高于对照组(P＜0.05)；两组患者PaCO2较治疗前下降(P＜0.05),且观察组低于对照组(P＜0.05)；两组患者PaO2较治疗前上升(P＜0.05),且观察组高于对照组(P＜0.05)；急性加重方面,在整个研究期间,观察组发生急性加重的患者少于对照组,且观察组低于对照组(P＜0.05)。结论:在常规西药维持治疗的基础上联合自拟加味参苓白术散治疗慢性阻塞性肺疾病稳定期(肺脾气虚型)具有良好的临床疗效,能够有效提高日常运动能力、改善心肺功能、减轻临床症状,并显著降低急性加重风险,值得推广及应用。

  关键词： ; ; ; 

   

  Abstract: 【】Objective: To evaluate the clinical efficacy of a self-formulated modified Shenling Baizhu Powder in patients with stable chronic obstructive pulmonary disease (COPD) classified as the lung-spleen qi deficiency type.Methods: A total of 220 patients with stable COPD and lung-spleen qi deficiency syndrome were randomly assigned to a control group (n = 110) and an observation group (n = 110) . Both groups continued conventional Western medicine maintenance therapy. The control group received a placebo, whereas the observation group received granules of a self-formulated modified Shenling Baizhu Powder. The treatment course lasted 12 weeks. Before and after the treatment, the COPD Assessment Test (CAT) score, 6-minute walk distance (6MWD), arterial blood gas parameters, and traditional Chinese medicine (TCM) syndrome scores were assessed, and the clinical efficacy was evaluated. Acute exacerbations during the study period were also recorded.Results: After treatment, the overall clinical response rate in the observation group was significantly higher than that in the control group 92.73% (102/110) vs. 80.00% (88/110), P<0.05. Both groups showed significant reductions in CAT scores and TCM syndrome scores compared with baseline (all P<0.05), with the observation group achieving significantly lower scores than the control group (all P<0.05). The 6-minute walk test (6MWT) distance increased significantly from baseline in both groups (P <0.05), and the observation group had a significantly greater increase than the control group (P< 0.05). PaCO? levels decreased significantly from baseline in both groups (P<0.05), and the observation group showed significantly lower PaCO? than the control group (P<0.05). PaO? levels increased significantly from baseline in both groups (P<0.05), and the observation group had significantly higher PaO? than the control group (P<0.05). Regarding acute exacerbations, during the entire study period, the number of patients experiencing acute exacerbations was lower in the observation group than in the control group, and the difference was statistically significant (P<0.05).Conclusion: The addition of self-formulated modified Shenling Baizhu Powder to conventional Western medicine maintenance therapy demonstrates favorable clinical efficacy for stable COPD patients with lung-spleen qi deficiency syndrome. It effectively improves daily exercise capacity and cardiopulmonary function, alleviates clinical symptoms, and significantly reduces the risk of acute exacerbation, warranting further clinical application and promotion.

  Key words: : COPD; syndrome of lung-spleen qi deficiency; modified Shenling Baizhu Powder; clinical effect

  提交时间：2026-08-21

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• 序号	提交日期	编号	操作
  1	2026-06-14	10.12201/bmr.202608.00041V1	下载

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