通讯作者: 林仁敬, 1093025592@qq.com

DOI：10.12201/bmr.202512.00076

Clinical observation on the treatment of slow transit constipation with blood deficiency and intestinal dryness syndrome by modified Runchang Decoction

• 摘要：目的 研究润肠方加减治疗慢传输型便秘血虚肠燥证的临床疗效及安全性。方法 将72例病例随机分为2组。润肠方加减组为治疗组,琥珀酸普卢卡必利片组为对照组,分别给予相应的治疗药物。实际完成观察64例,每组32例,疗程均为4周。记录其疗效指数及中医证候积分、不透X线标志物残留数变化情况。 结果 治疗组与对照组总有效率分别为90.63%、71.88%;治疗组与对照组临床疗效比较,差异有统计学意义(P＜0.05)。治疗前后组内比较,2组总积分、主要症状积分、标志物残留差异均有统计学意义(P＜0．05),治疗组次症积分具有统计学意义(P＜0．05);两组治疗后比较,总积分、主要症状与次症积分、标志物残留差异有统计学意义(P＜0．05)。 结论 润肠方加减可有效用于治疗慢传输型便秘血虚肠燥证。

  关键词： 润肠方加减; 慢传输型便秘; 血虚肠燥证

   

  Abstract: Objective Through clinical observation, this paper discusses the clinical efficacy and safety of modified Runchang Decoction in the treatment of slow transit constipation （STC）with blood deficiency and intestinal dryness syndrome. Method Seventy-two patients with STC were divided into treatment group and control group. The treatment group was administered modified Runchang Decoction, while the control group was administered prucalopride succinate tablets for 4 weeks. Among these, 32 cases in each group underwent actual observation. The clinical efficacy, TCM syndrome score, and marker residue number were statistically evaluated posttreatment. Results At the con-clusion of the treatment period, the treatment group exhibited an effective rate of 90.63%, surpassing the control group’s rate of 71.88%. There was significant differ-ence between the two groups (P < 0.05). Comparing both groups before and after treatment, the treatment group showed significant improvements in TCM syndrome to-tal score, main symptom score, and secondary symptom score (P < 0.05). In contrast, the control group displayed notable changes in TCM syndrome total score, main symp-tom score, and secondary symptom score (P < 0.05), with significant differences in TCM syndrome total score, main symptom score, secondary symptom score, and mark-er residue number between the two groups (P< 0.05). Conclusion “modified Run-chang Decoction” is quite effective for blood deficiency and intestinal dryness syndrome of slow transit constipation.

  Key words: modified Runchang Decoction; Slow transit constipation; Blood Deficiency and Intesti-nal Dryness Syndrome

  提交时间：2025-12-29

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• 序号	提交日期	编号	操作
  1	2025-11-02	10.12201/bmr.202512.00076V1	下载

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