通讯作者: 郑恒恒, 13519681466@163.com

DOI：10.12201/bmr.202608.00007

Molecular Mechanisms of Short-Chain Fatty Acid-Mediated Gut-Bone Axis in Regulating Fracture Healing and Progress of Integrated Chinese and Western Medicine Interventions

• 摘要：骨折愈合是一个涉及炎症反应、组织修复与骨重塑的复杂多阶段生物学过程,受细胞、分子及系统微环境等多重因素调控。肠-骨轴作为连接肠道微生态与骨骼代谢的关键跨器官调控通路,其功能紊乱与骨折延迟愈合、骨不连等并发症密切相关。短链脂肪酸(short-chain fatty acids, SCFAs)作为肠道菌群厌氧发酵膳食纤维等底物产生的主要代谢产物,是肠-骨轴功能实现的核心媒介,可通过直接作用于骨组织细胞或间接调控免疫、内分泌及营养代谢等途径,精准调控骨折愈合的全过程。本文系统梳理SCFAs的生成代谢特征,深入解析其介导肠-骨轴调控骨折愈合的分子机制,总结西医靶向干预与中医辨证施治的研究进展,探讨中西医结合干预的协同效应与临床应用前景,为骨折愈合的临床治疗提供新的思路与靶点,为中西医结合防治骨代谢相关疾病提供理论支撑。

  关键词： 短链脂肪酸; 肠-骨轴; 骨折愈合; 分子机制; 中西医结合干预

   

  Abstract: SFracture healing is a complex, multi-stage biological process involving inflammatory response, tissue repair, and bone remodeling, regulated by multiple factors including cellular, molecular, and systemic microenvironmental elements. The gut-bone axis, a key trans-organ regulatory pathway connecting the gut microbiome with bone metabolism, is closely associated with complications such as delayed fracture healing and nonunion when dysfunctional. Short-chain fatty acids (SCFAs), the primary metabolites produced by the anaerobic fermentation of dietary fibers and other substrates by gut microbiota, serve as the core mediators of the gut-bone axis. They can precisely regulate the entire process of fracture healing through direct actions on bone tissue cells or indirect modulation of immune, endocrine, and nutritional metabolic pathways. This article systematically reviews the generation and metabolic characteristics of SCFAs, deeply analyzes the molecular mechanisms by which they mediate the gut-bone axis in regulating fracture healing, and summarizes research progress in both Western medicine–targeted interventions and Traditional Chinese Medicine syndrome differentiation and treatment. It focuses on exploring the synergistic effects and clinical application prospects of integrated Chinese and Western medicine interventions, aiming to provide novel insights and targets for the clinical management of fracture healing, and to offer theoretical support for the integrated prevention and treatment of bone metabolism–related diseases.

  Key words: SShort-chain fatty acids; Gut-bone axis; Fracture healing; Molecular mechanisms; Integrative Chinese and Western medicine interventions

  提交时间：2026-08-04

  版权声明：作者本人独立拥有该论文的版权，预印本系统仅拥有论文的永久保存权利。任何人未经允许不得重复使用。
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• 序号	提交日期	编号	操作
  1	2026-05-24	10.12201/bmr.202608.00007V1	下载

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