通讯作者: 倪敏, 13505157926@163.com

DOI：10.12201/bmr.202606.00044

Research Progress on Neuromodulation Therapy for Functional Anorectal Disorders

• 摘要：功能性肛门直肠疾病（Functional Anorectal Disorders, FARDs）是临床上常见的功能性疾病，严重影响患者生活质量，而目前传统治疗手段临床疗效有限，效果不尽如人意。近年来，神经调控在FARDs领域取得了显著进展，其中，骶神经刺激在大便失禁领域积累了较为充分的循证医学证据；胫神经刺激和阴部神经刺激显示出良好的疗效与安全性；迷走神经刺激在改善胃肠动力方面展现出潜在价值，经颅磁刺激以及穴位刺激等无创神经调控技术亦展现出广阔的应用前景。本综述旨在系统梳理、总结并探讨各类中枢及外周神经调控技术在FARDs治疗中的最新研究进展、作用机制，希望为未来的临床应用与研究提供参考。

  关键词： 神经调控；功能性排便障碍；功能性大便失禁；功能性肛门直肠痛; ; ; 

   

  Abstract: Functional anorectal disorders (FARDs) are common functional gastrointestinal conditions that significantly impair patients’ quality of life. However, conventional therapeutic approaches often provide limited clinical benefits and remain unsatisfactory for many patients. In recent years, neuromodulation has emerged as a promising therapeutic strategy and has achieved considerable progress in the management of FARDs. Among these modalities, sacral nerve stimulation has accumulated substantial evidence supporting its efficacy, particularly in the treatment of fecal incontinence. Tibial nerve stimulation and pudendal nerve stimulation have also demonstrated favorable efficacy and safety profiles. Vagus nerve stimulation has shown potential in improving gastrointestinal motility, while non-invasive neuromodulation techniques, including transcranial magnetic stimulation and acupoint stimulation, have exhibited broad clinical prospects. This review aims to systematically summarize and discuss the latest advances and underlying mechanisms of both central and peripheral neuromodulation therapies for FARDs, with the goal of providing insights for future clinical applications and research.

  Key words: Neuromodulation; Functional defecation disorders; Functional fecal incontinence; Functional anorectal pain

  提交时间：2026-06-12

  版权声明：作者本人独立拥有该论文的版权，预印本系统仅拥有论文的永久保存权利。任何人未经允许不得重复使用。
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• 序号	提交日期	编号	操作
  1	2026-04-15	10.12201/bmr.202606.00044V1	下载

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