Solitary Rectal Ulcer Syndrome in a Pediatric Patient: A Case Report and Literature Review

Corresponding author: Wenying Hao, dudu89@163.com

DOI: 10.12201/bmr.202506.00034

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  Abstract: This study reports the clinical management of a pediatric case of solitary rectal ulcer syndrome (SRUS) and explores diagnostic and therapeutic strategies through histopathological analysis and literature review. A male patient aged 12 years and 9 months presented with a 1-year history of constipation and intermittent hematochezia over 2 months. Laboratory investigations were unremarkable. Colonoscopy revealed multiple ulcerative lesions covered with whitish exudate in the distal rectum (4–9 cm from the anal verge). Histopathological examination confirmed crypt architectural distortion and fibromuscular hyperplasia of the lamina propria, consistent with SRUS diagnostic criteria. A comprehensive therapeutic regimen was implemented, including dietary modification, defecation behavior training, mucosal repair with Kangfuxin solution, and osmotic laxative therapy (lactulose). After 3 months of standardized management, clinical symptoms resolved. Follow-up endoscopy demonstrated significant lesion regression (residual irregular superficial erosion at 8 cm from the anal verge), with histopathological improvement characterized by mild crypt distortion, chronic inflammatory cell infiltration, and smooth muscle hyperplasia. Longitudinal follow-up validated the efficacy of this integrated therapeutic approach. By synthesizing clinical case features with systematic literature review, this study aims to enhance clinicians understanding and management of SRUS in pediatric populations.

  Key words: ; ; ; ; 

  Submit time: 14 June 2025

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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