通讯作者: 郝雯颖, dudu89@163.com

DOI：10.12201/bmr.202506.00034

Solitary Rectal Ulcer Syndrome in a Pediatric Patient: A Case Report and Literature Review

• 摘要：本文报道1例儿童孤立性直肠溃疡综合征(solitary rectal ulcer syndrome,SRUS)的临床诊疗过程,并通过病理特征分析结合文献复习探讨诊疗策略。患儿男性,12岁9个月,主诉“便秘1年余,间断便血2月”就诊,实验室检查未见明显异常后,经结肠镜检查发现直肠远段(距肛门4～9cm)可见多发性溃疡病灶,表面覆白苔；组织病理学检测证实隐窝结构紊乱及固有层纤维增生,符合SRUS诊断标准。实施饮食结构调整联合排便行为干预疗法,辅以康复新液黏膜修复及乳果糖渗透性导泻治疗。经3个月规范管理后,患儿临床症状缓解,复查内镜显示病灶范围显著缩小(距肛门8cm处残留不规则浅表糜烂),病理学改善表现为隐窝结构稍减少、间质慢性炎细胞浸润及平滑肌组织增生。随访观察证实该综合治疗方案的有效性。本研究通过临床病例特征分析结合文献系统回顾,旨在提升临床医师对该疾病的认知水平及诊疗能力。

  关键词： 孤立性直肠溃疡综合征; 儿童; 发病机制; 内镜; 病理

   

  Abstract: This study reports the clinical management of a pediatric case of solitary rectal ulcer syndrome (SRUS) and explores diagnostic and therapeutic strategies through histopathological analysis and literature review. A male patient aged 12 years and 9 months presented with a 1-year history of constipation and intermittent hematochezia over 2 months. Laboratory investigations were unremarkable. Colonoscopy revealed multiple ulcerative lesions covered with whitish exudate in the distal rectum (4–9 cm from the anal verge). Histopathological examination confirmed crypt architectural distortion and fibromuscular hyperplasia of the lamina propria, consistent with SRUS diagnostic criteria. A comprehensive therapeutic regimen was implemented, including dietary modification, defecation behavior training, mucosal repair with Kangfuxin solution, and osmotic laxative therapy (lactulose). After 3 months of standardized management, clinical symptoms resolved. Follow-up endoscopy demonstrated significant lesion regression (residual irregular superficial erosion at 8 cm from the anal verge), with histopathological improvement characterized by mild crypt distortion, chronic inflammatory cell infiltration, and smooth muscle hyperplasia. Longitudinal follow-up validated the efficacy of this integrated therapeutic approach. By synthesizing clinical case features with systematic literature review, this study aims to enhance clinicians understanding and management of SRUS in pediatric populations.

  Key words: ; ; ; ; 

  提交时间：2025-06-14

  版权声明：作者本人独立拥有该论文的版权，预印本系统仅拥有论文的永久保存权利。任何人未经允许不得重复使用。
• html

• 图表

• 邝文健, 郑拓, 戴灵爱, 周亭君, 罗胜. Mounier-Kuhn综合征二例并文献复习. 2025. doi: 10.12201/bmr.202504.00057

  罗自豪, 耿　刚, 李少军. 儿童肺炎支原体脑炎1例并文献复习. 2024. doi: 10.12201/bmr.202408.00042

  张卓. 泪囊区淋巴上皮癌1例并文献复习. 2025. doi: 10.12201/bmr.202501.00073

  孟黎明, 李晓, 姚红梅. 合并多囊卵巢综合征的卵巢类固醇细胞瘤1例. 2025. doi: 10.12201/bmr.202505.00034

  陈思, 王立杰. 原发性直肠黑色素瘤病例报道. 2023. doi: 10.12201/bmr.202310.00004

  丁凯玥, 符德元. 老年女性乳腺罗道夫病1例报告并文献复习. 2025. doi: 10.12201/bmr.202503.00076

  杨鸿圣, 俞石芳. ABO血型次侧不相合肺移植患者过客淋巴细胞综合征1例及输血策略探讨. 2025. doi: 10.12201/bmr.202504.00002

  王羚钰, 徐红. 老年骨量-肌量减少性肥胖综合征的治疗进展. 2024. doi: 10.12201/bmr.202411.00064

  高春柳, 张晗, 褚梦圆, 许凯凯, 项馨, 闫颖. Isthmin1蛋白在多囊卵巢综合征中作用机制的进展. 2024. doi: 10.12201/bmr.202411.00004

  岳晓雪, 赵群. 年轻化疗耐药绒癌病例1例及文献复习. 2024. doi: 10.12201/bmr.202411.00007

• 序号	提交日期	编号	操作
  1	2025-03-28	bmr.202506.00034V1	下载

• 公开评论  匿名评论  仅发给作者 提交评论