Exploration of the Pathogenic characteristics of Hepatocellular Carcinoma Liver Depression and Spleen Deficiency Based on the

Corresponding author: Zhang Xue, 1736522483@qq.com

DOI: 10.12201/bmr.202506.00030

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  Abstract: Hepatocellular carcinoma is a prevalent malignant tumor with high morbidity and mortality.Current therapeutic outcomes for liver cancer are far from ideal.Emerging evidence highlights the critical role of gut microbiota and bile acid interactions in liver cancer progression through specific signaling pathways.Traditional Chinese medicine theory identifies “liver depression and spleen deficiency ”as the key pathogenic mechanisms of liver cancer,with disorders of intestinal flora and abnormal bile acid metabolism as microcosmic reflections.This review integrates Traditional Chinese medicine principles with clinical research to elucidate the gut microbiota-bile acid axis in liver cancer, offering effective strategies for its clinical management.

  Key words: intestinal flora; bile acid; hepatocellular carcinoma; Liver Depression and Spleen Deficiency

  Submit time: 14 June 2025

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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