Identification of links between sleepiness and gut microbiota using Mendelian randomization analysis

Corresponding author: Hua Lin, hualin7750@139.com

DOI: 10.12201/bmr.202409.00006

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  Abstract: Objective Daytime sleepiness can be caused by a variety of reasons, such as sleep apnea (OSA), insomnia, poor sleep hygiene, etc. However, only about half of OSA patients complain of daytime sleepiness. In addition, after adequate sleep and effective treatment of OSA, a small number of patients still have symptoms of daytime sleepiness. The exact reasons for sleepiness and differences in the population are not clear. Numerous evidences have shown that the gut microbiota is closely associated with sleep disorders and waikefulness. This study will investigate whether there is an association between daytime sleepiness and gut microbiota, and provide a refence for further understanding of sleepiness. Methods Two-sample Mendelian randomization (Mr) analysis was performed using genome-wide association study (GWAS) data, with gut microbiota as an exposure factor, sleepiness as an outcome factor, and single nucleotide polymorphisms (SNPs) as an instrumental variable, and inverse variance weighting (IVW) was used to screen potential pathogenic gut microbes for daytime sleepiness. The robustness of the results of the Mr analysis was ensured by using different sensitivity analyses. Results Based on the results of the multiple analyses, Butyricimonas, Peptococcus, Bilophila, Anaerofilum, Ruminococcus gnavus and Coprococcus were relatively abundant in the sleepiness population, while Oscillospira and Desulfovibrio were relatively less abundant. Conclusion The results of this study indicated that there was an imbalance of gut microbiota in sleepiness people. Whether the adjustment of intestinal flora structure by taking measures (such as the change of dietary structure, the use of probiotics, etc.) Is a new way to improve daytime sleepiness remains to be confirmed by further studies in the future.

  Key words: Daytime sleepiness; Gut microbiota; Microbiota-gut-brain axis; Single Nucleotide Polymorphisms (SNP); Mendelian randomization

  Submit time: 3 September 2024

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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