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Corresponding author: Yuanjianlie, yuanjianlie@zju.edu.cn

DOI: 10.12201/bmr.202501.00029

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  Abstract: Backgroud There have been limited studies on the etiology of pituitary adenoma in the past. Therefore, our goal was to investigate the potential causal relationship between gut microbiota and pituitary adenoma.Method Two-sample mendelian randomization(MR) analysis was conducted in this study using genome-wide association studies (GWAS) summary statistics from the MiBioGen(including 211 gut microbiota taxa) and FinnGen consortiums R9 release data(1,402 cases and 375,875 controls) to evaluate the causal association between gut microbiota and pituitary adenoma.Result We found that the genus RuminococcaceaeUCG004 (OR = 1.39, 95% CI: 1.00-1.93, P = 0.049), Fusicatenibacter (OR=1.65, 95%CI:1.10-2.49, P=0.017), and family Acidaminococcaceae (OR=1.99, 95%CI:1.25-3.17, P=0.004) may increase the risk of pituitary adenoma. Conversely, the genus Ruminiclostridium5 (OR=0.63, 95%CI:0.41-0.99, P=0.043), genus Eisenbergiella (OR=0.70,95%CI:0.55-0.91, P=0.007), class Negativicutes (OR=0.57, 95%CI:0.36-0.89, P=0.014), and phylum Euryarchaeota (OR=0.78, 95% CI:0.64-0.97, P=0.022) exhibited a negative correlation with pituitary adenoma.Sensitivity analyses indicated the absence of pleiotropy and heterogeneity.

  Key words: Pituitary; adenoma ·Gut; microbiota ·Mendelian; randomization analysis

  Submit time: 10 January 2025

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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