Etiology and pathogenesis of Modic type 1 changes

Corresponding author: 申泽涛, zetaoshen@i.smu.edu.cn

DOI: 10.12201/bmr.202505.00049

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  Abstract: Low back pain is a common and serious health issue in modern society, and it is one of the major causes of disability. Modic type 1 changes (MC1) is closely associated with low back pain and intervertebral disc degeneration, therefore MC1 has drawn wide attention. The study of the etiology and pathogenesis of MC1 will provide new methods for alleviating low back pain and improving intervertebral disc degeneration which has great importance. In recent years, relevant researches have been continuously deepened. The author will review the literature and summarize the etiology and pathogenesis of MC1 from the aspects of low virulent infection, endplate damage, local inflammation and autoimmune reaction. This article will help to provide the target of clinical interventions and direction of future researches related to MC1.

  Key words: Osteomyelitis, Inflammation, Autoimmunity, Vertebral body, Endplate damage

  Submit time: 30 May 2025

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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  1	2025-04-04	bmr.202505.00049V1	Download

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