Discussing the pathogenesis and treatment of colorectal cancer with Iron Death on the basis of “health and evil all originate from yin and yang”.

DOI: 10.12201/bmr.202505.00043

•  

  Abstract: Colorectal cancer (CRC) is a kind of digestive tract tumor characterized by malignant proliferation of intestinal mucosa, with insidious symptoms in the early stage and abdominal pain, blood in stool, intestinal obstruction and metastasis-related symptoms in the late stage, with poor prognosis. Ferroptosis and colorectal cancer are closely related. Iron death is an iron-dependent mode of cell death that can be achieved through the iron metabolism pathway, lipid metabolism pathway, and amino acid metabolism pathway for bidirectional regulation of colorectal cancer cells.This paper integrates the theory of health and evil all originate from yin and yang ShengQiTongTianLun of Suwen with the mechanism of ferroptosis, and explains that ferroptosis can not only induce the death of cancer cells and gather healthy Qi, but also promote the malignant transformation of normal cells and generate evil Qi, and the mechanism of its bidirectional regulation of diseases has a common law with that of yin and yang in the theory of yin and yang in which yin and yang are opposing - transforming - and growing. Its two-way regulation mechanism on diseases has a common law with the Yin-Yang theory of yin-yang opposition-transformation-dissipation. Based on the theory of health and evil all originate from yin and yang ferroptosis in the development and treatment of colorectal cancer, and then puts forward the traditional Chinese medicine (TCM) therapeutic method of supporting healthy Qi, leveling hyperactivity of yang, and breaking yin condensation, which is expected to provide TCM theoretical support for the modern study of CRC, and to provide new ideas for the research and treatment of colorectal cancer.

  Key words: Colorectal cancer; Ferroptosis; Yin-Yang theory; Theoretical discussion

  Submit time: 28 May 2025

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
• html

• 图表

• Wang Xia, Qian Rui, Ma Di. Discussion on the treatment of subacute thyroiditis based on the theory of yin and yang of internal meridian. 2025. doi: 10.12201/bmr.202503.00083

  Yang Zongliang, LUO Min. Treatment of Colorectal Polyps Based on The Theory of. 2024. doi: 10.12201/bmr.202412.00046

  HU Jie, LIU Yun-nan. Bibliometric analysis of literatures related to colorectal cancer organoids based on CiteSpace. 2024. doi: 10.12201/bmr.202409.00036

  Tang jianjun, zhang weiyuan, liu chuanlei. Clinical significance of detecting blood D-dimer and CEA levels before treatment in colorectal cancer patients. 2024. doi: 10.12201/bmr.202409.00023

  Yang yijie, Xu lu. Analysis of Risk Factors for Liver Surgical Site Infection following synchronous resection for Colorectal Cancer Liver Metastasis.YANG Jiale,YANG Yijie,XU Lu. The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China 215006. 2024. doi: 10.12201/bmr.202411.00037

  Feng Zhenbo, Hu Jie. The combined prognostic value of MSI, DD, and CA19-9 in colorectal cancer patients who underwent radical resection. 2025. doi: 10.12201/bmr.202505.00020

  yanglin, yangyang. Research Progress on Autophagy-Dependent Ferroptosis in Cancer. 2024. doi: 10.12201/bmr.202410.00029

  YU Yunfeng, YANG Xinyu, HU Gang, Tang Xudong, YOU Yunge. Based on the Theory of Yin and Yang to Explore the Mechanism of Autophagy in Ulcerative Colitis and Chinese Medicine Intervention Strategies. 2025. doi: 10.12201/bmr.202501.00001

  WangZiyi, KeShiyan, LiuQiang. Exploring the Pathogenesis and Management Strategies of Presyncope from the Perspective of the ascending the Qing and descending the Zhuo Theory. 2025. doi: 10.12201/bmr.202505.00052

  CHEN Jiabin, xu guoshu, 柴. . 2024. doi: 10.12201/bmr.202412.00035

• ID	Submit time	Number	Download
  1	2025-05-14	bmr.202505.00043V1	Download

• Public  Anonymous  To author only Submit Comments