通讯作者: 徐婧秋, 17714955680@163.com

DOI：10.12201/bmr.202505.00043

Discussing the pathogenesis and treatment of colorectal cancer with Iron Death on the basis of “health and evil all originate from yin and yang”.

• 摘要：结直肠癌(Colorectal cancer, CRC)是一种以肠道黏膜恶性增殖为特征的消化道肿瘤,早期症状隐匿,晚期常表现为腹痛、便血、肠梗阻及转移相关症状,预后较差。铁死亡和结直肠癌密切相关,铁死亡是一种依赖铁的细胞死亡方式,可通过铁代谢途径,脂质代谢途径,氨基酸代谢途径,实现对结直肠癌细胞的双向调控。《素问.生气通天论》化用而来的“生气邪气皆本于阴阳”理论可与铁死亡的机制相融合,以阐释铁死亡既能诱导癌细胞死亡而聚生气,也能促进正常细胞的恶变而生邪气,其对疾病的其双向调节作用机制与阴阳理论中阴阳对立,阴阳转化,阴阳消长有共性规律。该研究基于“生气邪气皆本于阴阳”理论探讨铁死亡在结直肠癌发展和治疗中的作用,继而提出扶正气,平阳亢,破阴凝的中医治疗方法,有望为CRC 现代研究提供中医理论支持,为结直肠癌的研究与治疗提供新的思路。

  关键词： 结直肠癌; 铁死亡; 阴阳理论; 理论探讨

   

  Abstract: Colorectal cancer (CRC) is a kind of digestive tract tumor characterized by malignant proliferation of intestinal mucosa, with insidious symptoms in the early stage and abdominal pain, blood in stool, intestinal obstruction and metastasis-related symptoms in the late stage, with poor prognosis. Ferroptosis and colorectal cancer are closely related. Iron death is an iron-dependent mode of cell death that can be achieved through the iron metabolism pathway, lipid metabolism pathway, and amino acid metabolism pathway for bidirectional regulation of colorectal cancer cells.This paper integrates the theory of health and evil all originate from yin and yang ShengQiTongTianLun of Suwen with the mechanism of ferroptosis, and explains that ferroptosis can not only induce the death of cancer cells and gather healthy Qi, but also promote the malignant transformation of normal cells and generate evil Qi, and the mechanism of its bidirectional regulation of diseases has a common law with that of yin and yang in the theory of yin and yang in which yin and yang are opposing - transforming - and growing. Its two-way regulation mechanism on diseases has a common law with the Yin-Yang theory of yin-yang opposition-transformation-dissipation. Based on the theory of health and evil all originate from yin and yang ferroptosis in the development and treatment of colorectal cancer, and then puts forward the traditional Chinese medicine (TCM) therapeutic method of supporting healthy Qi, leveling hyperactivity of yang, and breaking yin condensation, which is expected to provide TCM theoretical support for the modern study of CRC, and to provide new ideas for the research and treatment of colorectal cancer.

  Key words: Colorectal cancer; Ferroptosis; Yin-Yang theory; Theoretical discussion

  提交时间：2025-05-28

  版权声明：作者本人独立拥有该论文的版权，预印本系统仅拥有论文的永久保存权利。任何人未经允许不得重复使用。
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• 序号	提交日期	编号	操作
  1	2025-05-14	bmr.202505.00043V1	下载

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