通讯作者: 刘传磊, cz_lchl@sina.com

DOI：10.12201/bmr.202409.00023

Clinical significance of detecting blood D-dimer and CEA levels before treatment in colorectal cancer patients

• 摘要：目的 研究治疗前血清CEA和D-二聚体的异常表达与结直肠癌临床病理资料的关系,并探讨其对结直肠癌复发转移及生存率的影响。方法 选取于2017年1月至2018年12月在我院首次诊断结直肠癌并行根治性手术的患者209例,检测治疗前血清D-二聚体和CEA水平,分析临床病理资料,并进行术后随访。结果 结直肠癌患者治疗前血D-二聚体和CEA阳性率均明显高于对照组(P< 0.001)。治疗前血D-二聚体和CEA与结直肠癌术后复发和总体生存等均相关(P<0.05)。治疗前血D-二聚体和CEA存在相关性(P<0.05)。治疗前血D-二聚体和CEA同时阳性是影响结直肠癌术后复发和生存的独立因素。治疗前D-二聚体和CEA同时阳性对总体生存期影响的ROC曲线下面积为0.723(P<0.001)。结论 治疗前D-二聚体和CEA对结直肠癌诊断和预后判断有重要价值。治疗前D-二聚体和CEA同时阳性对结直肠癌术后生存评估的准确性效果确切。联合检测有重要价值。且二者有相关性,对理解结直肠癌的行为提供思路。

  关键词： D-二聚体; CEA; 治疗前; 结直肠癌; 预后; ROC曲线

   

  Abstract: Objective To investigate the relationship between the abnormal expression of pre-treatment serum CEA and D-dimer and the clinicopathological data of colorectal cancer, and to explore they effect on the recurrence, metastasis and survival rate of colorectal cancer. Methods A total of 209 patients who were diagnosed with colorectal cancer for the first time in our hospital from January 2017 to December 2018 and underwent radical surgery were enrolled, and the serum levels of D-dimer and CEA before treatment were measured, the clinicopathological data were analyzed, and the postoperative follow-up was performed. Results The positive rates of D-dimer and CEA in colorectal cancer patients were significantly higher than those in the control group (P<0.001). Pre-treatment blood D-dimer and CEA were associated with recurrence and overall survival of colorectal cancer after surgery (P<0.05). There was a correlation between pre-treatment blood D-dimer and CEA (P<0.05). Positive pre-treatmentblood D-dimer and CEA are independent factors affecting the recurrence and survival of colorectal cancer after surgery. The area under the ROC curve of the effect of both positive pre-treatmentD-dimer and CEA on overall survival was 0.723 (P<0.001). Conclusion Pre-treatment D-dimer and CEA have important value in the diagnosis and prognosis of colorectal cancer. Both positive D-dimer and CEA before treatment had a definite effect on the accuracy of postoperative survival assessment of colorectal cancer. Co-testing is of great value. And the two are related, which provides ideas for understanding the behavior of colorectal cancer.

  Key words: D-dimer; CEA; Pre-treatment; Colorectal cancer; Prognosis; ROC curve

  提交时间：2024-09-13

  版权声明：作者本人独立拥有该论文的版权，预印本系统仅拥有论文的永久保存权利。任何人未经允许不得重复使用。
• html

• 图表

• 熊淑艳, 胡杰, 刘云南. 基于CiteSpace对结直肠癌类器官相关文献的计量学分析. 2024. doi: 10.12201/bmr.202409.00036

  杨家乐, 杨毅杰, 徐露. 结直肠癌肝转移同期手术中肝脏术区感染危险因素分析. 2024. doi: 10.12201/bmr.202411.00037

  罗姝, 杨宗亮, 罗敏. 基于《内经》“汁沫与血相抟”理论论治结直肠息肉. 2024. doi: 10.12201/bmr.202412.00046

  牛亚丹. 外周血炎症指标对髋部骨折患者术后并发下肢深静脉血栓的诊断价值. 2024. doi: 10.12201/bmr.202408.00016

  李欣鑫, 陈嘉斌, 徐国暑, 柴可群. 中医药通过调控肠道微生态防治结直肠癌转移的研究进展. 2024. doi: 10.12201/bmr.202412.00035

  刘英超, 张丽娜, 张秋月, 李震, 田佳. 老年重症肺炎患者凝血功能指标变化及意义. 2024. doi: 10.12201/bmr.202411.00035

  冀鹏磊, 髙崴崴, 李佳霖, 刘待见, 王昱林. 免疫炎症相关指数与重症肺炎转归相关性分析. 2024. doi: 10.12201/bmr.202409.00062

  张楚楚, 毛启远, 刘艺, 林洪生, 李海燕. 互联网诊疗在肿瘤患者间的应用展望. 2023. doi: 10.12201/bmr.202312.00026

  周圆, 刘静, 潘亚雯, 任政. 机器人甲状腺切除术在甲状腺癌治疗研究进展. 2024. doi: 10.12201/bmr.202411.00030

  杨庆松, 张燕洁, 刘燕, 刘振. 加味散偏汤治疗肝郁血瘀型紧张型头痛临床观察. 2024. doi: 10.12201/bmr.202412.00019

• 序号	提交日期	编号	操作
  1	2024-08-11	bmr.202409.00023V1	下载

• 公开评论  匿名评论  仅发给作者 提交评论