通讯作者: 田佳, lceytianjia@163.com

DOI：10.12201/bmr.202411.00035

Changes and Significance of Coagulation Function Indicators in Elderly Patients with Severe Pneumonia

• 摘要：目的 分析老年重症肺炎患者凝血功能相关指标水平变化，并探讨其临床意义。方法 选取2022年1月至2023年12月聊城市第二人民医院收治的老年重症肺炎患者127例作为观察组，选取同期收治的普通肺炎患者135例作为对照组，收集两组患者入院24小时内凝血功能相关指标，包括凝血酶原时间（prothrombin time, PT）、纤维蛋白原（fibrinogen, FIB）、活化部分凝血活酶时间（activated partial thromboplastin time, APTT）、凝血酶时间（thrombin time, TT）、D二聚体（D-dimer, D-D）、血小板计数（platelet count, PLT），利用统计学软件比较两组患者凝血指标阳性率及结果水平差异。结果 与对照组相比，观察组患者吸烟史、基础疾病既往史比例显著增高，观察组PT、D-D结果阳性率显著增高，差异均有统计学意义（P＜0.05）；FIB、APTT、TT、PLT等结果两组阳性率无显著差异；观察组PT、TT、D-D结果显著高于对照组（P＜0.05），而PLT结果显著低于对照组（P＜0.05），两组之间FIB、APTT结果水平无差异（P＞0.05）。结论 重症肺炎患者常发生凝血功能异常，开展凝血功能相关指标检测对评估患者病情具有重要意义。

  关键词： 重症肺炎; 凝血功能; 纤维蛋白原; D二聚体; 血小板计数

   

  Abstract: Objective To analyze the changes in coagulation function related indicators in elderly patients with severe pneumonia and explore their clinical significance. Methods 127 elderly patients with severe pneumonia admitted to the Second Peoples Hospital of Liaocheng from January 2022 to December 2023 were selected as the observation group. 135 patients with common pneumonia admitted during the same period were randomly selected as the control group. Coagulation function related indicators, including prothrombin time (PT), fibrinogen (FIB), activated partial thromboplastin time (APTT), thrombin time（TT）,D-dimer (D-D), and platelet count (PLT), were collected within 24 hours of admission from the two groups of patients. Statistical software was used to compare the positive rate and level of coagulation indicators between the two groups of patients. Results Compared with the control group, the proportion of patients in the observation group with a history of smoking and underlying diseases was significantly increased. The positive rates of PT and D-D results in the observation group were also significantly increased, and the differences were statistically significant (P<0.05). There was no significant difference in the positive rates of FIB, APTT, TT, PLT and other results between the two groups; The PT, TT, and D-D results of the observation group were significantly higher than those of the control group (P <0.05), while the PLT results were significantly lower than those of the control group (P <0.05). There was no difference in the levels of FIB and APTT results between the two groups (P >0.05). Conclusion Severe pneumonia patients often experience coagulation dysfunction, and the detection of coagulation related indicators is of great significance for evaluating the patients condition.

  Key words: Severe pneumonia; Coagulation function; Fibrinogen; D-dimer; Platelet count

  提交时间：2024-11-16

  版权声明：作者本人独立拥有该论文的版权，预印本系统仅拥有论文的永久保存权利。任何人未经允许不得重复使用。
• html

• 图表

• 孙姚承, 汤建军, 张伟元, 刘传磊. 结直肠癌患者检测治疗前血D-二聚体和CEA的临床意义. 2024. doi: 10.12201/bmr.202409.00023

  冀鹏磊, 髙崴崴, 李佳霖, 刘待见, 王昱林. 免疫炎症相关指数与重症肺炎转归相关性分析. 2024. doi: 10.12201/bmr.202409.00062

  施明杰, 叶洪舟, 袁琛. 大环内酯类耐药肺炎支原体肺炎患儿发展为重症肺炎的危险因素分析及预测模型构建. 2024. doi: 10.12201/bmr.202409.00021

  沈煜宸, 杨敏. 高压氧联合外用蛇伤散治疗血循毒蛇咬伤后凝血功能障碍及肢体肿胀的研究. 2024. doi: 10.12201/bmr.202407.00060

  史洋溢, 吴勇. 血小板膜糖蛋白抗体的差异性分布对儿童原发免疫性血小板减少症临床疗效影响的研究并文献复习. 2024. doi: 10.12201/bmr.202407.00049

  何玲雁, 师金川, 程江豪, 朱明利. 肝素结合蛋白、NLR、LMR及PLR在HIV/AIDS患者免疫功能重建评估中的应用价值. 2024. doi: 10.12201/bmr.202408.00040

  姚泓哲, 郭鑫龙, 杨林瀛. FAP/ALB、NLPR对老年CAP严重程度的预测价值. 2024. doi: 10.12201/bmr.202412.00057

  詹海侠, 胡东, 张文婷, 顾影. 集束化护理模式对乳腺癌改良根治术后患者肩关节功能恢复及生命质量的影响. 2020. doi: 10.12201/bmr.202004.00015

  那春鑫. 高胆固醇血症患者脂质过氧化及抗氧化能力的变化. 2024. doi: 10.12201/bmr.202409.00053

  刘燕, 李姣, 康宏宇, 李露琪, 张潇潇, 徐子犊, 侯丽. 新型冠状病毒(COVID-19)肺炎防控专题服务构建研究. 2020. doi: 10.12201/bmr.202005.00249

• 序号	提交日期	编号	操作
  1	2024-11-11	bmr.202411.00035V1	下载

• 公开评论  匿名评论  仅发给作者 提交评论