通讯作者: 朱明利, mlzhhz@163.com

DOI：10.12201/bmr.202408.00040

The Application Value of Heparin Binding Protein, NLR, LMR, and PLR in Immune Function Reconstruction Evaluation in HIV/AIDS Patients

• 摘要：目的 探讨肝素结合蛋白（heparin binding protein，HBP）、中性粒细胞与淋巴细胞比值(neutrophil to lymphocyte ratio,NLR)、淋巴细胞与单核细胞比值(lymphocyte to monocyte ratio, LMR)及血小板与淋巴细胞比值(platelet to lymphocyte ratio,PLR)在人类免疫缺陷病毒（human immunodeficiency virus，HIV）感染者/获得性免疫缺陷综合征（acquired immunodeficiency syndrome，AIDS）患者免疫功能重建评估中的应用价值。 方法 收集浙江中医药大学附属杭州西溪医院2023年1月1日至2023年6月30日门诊HIV/AIDS患者，根据抗逆转录病毒治疗后患者CD4+T淋巴细胞计数分为免疫功能重建良好组和免疫功能重建不良组，比较两组HBP、NLR、LMR及PLR水平，采用受试者操作特征曲线（receiver operating characteristic curve ,ROC曲线）评估HBP、NLR、LMR及PLR在患者免疫功能重建中的应用价值。结果 免疫功能重建良好组的NLR、PLR明显高于免疫功能重建不良组（P<0.05）。免疫功能重建良好组的LMR明显低于免疫功能重建不良组（P<0.05）。而HBP在两组之间无明显差异（P>0.05）。HBP不能评估HIV/AIDS患者免疫功能重建是否良好（P>0.05）。LMR对评估HIV/AIDS患者免疫功能重建是否良好的效能最佳（曲线下面积0.803）；PLR次佳（曲线下面积0.796）；NLR较差（曲线下面积0.728）。结论 HBP不能评估HIV/AIDS患者免疫功能重建是否良好。NLR、LMR及PLR与HIV/AIDS患者的免疫功能紧密相关,可作为评估HIV/AIDS患者免疫功能重建是否良好的检测指标。

  关键词： 肝素结合蛋白；NLR；LMR；PLR； HIV/AIDS；免疫功能重建

   

  Abstract: Objective Exploring the application value of heparin binding protein (HBP), neutrophil to lymphocyte ratio (NLR), lymphocyte to monocyte ratio (LMR), and platelet to lymphocyte ratio (PLR) in the evaluation of immune function reconstruction in human immunodeficiency virus (HIV) infected individuals/acquired immunodeficiency syndrome (AIDS) patients. Methods Collect HIV/AIDS patients from the outpatient department of Hangzhou Xixi Hospital Affiliated to Zhejiang Chinese Medical University from January 1, 2023, to June 30, 2023. According to CD4+ T lymphocyte counts after antiretroviral treatment, categorize patients into groups with good immune function reconstruction and poor immune function reconstruction,Compare the levels of HBP, NLR, LMR, and PLR between two groups,The receiver operating characteristic curve (ROC curve) was used to evaluate the application value of HBP, NLR, LMR, and PLR in the reconstruction of patient immune function. Results The NLR and PLR of the group with good immune function reconstruction was significantly higher than that of the group with poor immune function reconstruction (P<0.05).The LMR of the group with good immune function reconstruction were significantly lower than those of the group with poor immune function reconstruction (P<0.05). The HBP between the two groups was no significant differences(P>0.05).HBP cannot evaluate whether immune function reconstruction is good in HIV/AIDS patients (P>0.05). LMR has the best efficacy in evaluating whether immune function reconstruction is good in HIV/AIDS patients (area under the curve 0.803); PLR is the second best (area under the curve 0.796); The NLR is poor (area under the curve 0.728). Conclusion HBP cannot evaluate whether immune function reconstruction is good in HIV/AIDS patients. NLR, LMR, and PLR are closely related to the immune function of HIV/AIDS patients and can be used as detection indicators to evaluate whether the immune function reconstruction of HIV/AIDS patients is good.

  Key words: Heparin binding protein； NLR；LMR；PLR；HIV/AIDS；Immune function reconstruction

  提交时间：2024-08-21

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• 序号	提交日期	编号	操作
  1	2024-06-08	bmr.202408.00040V1	下载

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