Research advances of natural killer cells at the maternal-fetal interface

Corresponding author: GaoTao, eyes-on-you@163.com

DOI: 10.12201/bmr.202505.00023

•  

  Abstract: Objective To summarize the role of macrophages and their polarization at the maternal fetal interface and their involvement in the pathogenesis of recurrent abortion. Methods The literatures on the role of macrophages in the maternal fetal interface during pregnancy in the databases of PubMed, China National Knowledge Infrastructure (CNKI),? web of science and Wanfang in recent 10 years were searched, and the role of macrophages and their polarization in the maternal fetal interface and their involvement in the pathogenesis of spontaneous abortion were summarized. results A total of 89 English literatures were retrieved. It was found that macrophages were involved in trophoblast invasion, spiral artery remodeling and the burial of apoptotic cells. The polarization balance of M1/M2 macrophages was a necessary condition for successful pregnancy, and the imbalance of M1/M2 during pregnancy was closely related to spontaneous abortion or recurrent abortion. Conclusion Taking macrophages as the starting point, this paper deeply discusses the specific mechanism between macrophages and normal pregnancy and spontaneous abortion, so as to provide new targets and ideas for exploring new therapies to improve pregnancy outcome.

  Key words: decidual macrophages; Hofbauer cells; Pregnancy; Maternal-fetal interface

  Submit time: 21 May 2025

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
• html

• 图表

• Long Yuanyuan, Pu Jiale, Zhang Zengyu, Shen Zihao, Zhang Jidong. ZHANG Jierong1, LONG Yuanyuan1, PU Jiale1, ZHANG Zengyu1,2, SHEN Zihao1, ZHANG Jidong1*(Hunan University of Chinese Medicine,Changsha,410208,China;. 2024. doi: 10.12201/bmr.202409.00005

  Cai Xudong. Macrophage Polarization Affects Chronic Kidney Disease:Based on Theory of “Harmful Hyperactivity and Responding Inhibition”. 2024. doi: 10.12201/bmr.202407.00027

  胡杨, sun guang chen. Investigating the Role of Escin in RAW 264.7 Macrophage Inflammatory Models. 2025. doi: 10.12201/bmr.202504.00003

  Research progress of red blood cell storage lesion. 2025. doi: 10.12201/bmr.202502.00021

  Yao Genwu, Wang Yanwei, Guo Jinyi, Li Lulu, Dang Wenbo, Song Ailin. Advances in single-cell sequencing in the breast cancer. 2024. doi: 10.12201/bmr.202407.00053

  Li Mengxin, Xue Qing, Ji Shuangyu, Chen Liang. Research progress on the pathway of aminoglycoside drugs entering hair cells. 2025. doi: 10.12201/bmr.202504.00046

  wangminggang, luojuan, mozhengyuan, chenxinxin, wangxiufeng. The Role of Immune Cells and Traditional Chinese Medicine in Acute-on-Chronic Liver Failure. 2025. doi: 10.12201/bmr.202504.00030

  LUAN Zhi-Yong. Research progress of stem cell therapy for Hirschsprung disease. 2024. doi: 10.12201/bmr.202410.00021

  Liang chunlan, Shi Qi, Liu lian, Zhong Jingxiang. Mesenchymal Stem Cells-Derived Exosomes and Ocular Immunologic Diseases. 2022. doi: 10.12201/bmr.202209.00019

  MAO Qian, luo qingqing. Clinical characteristics of premature rupture of membranes complicated with histological chorioamnionitis. 2025. doi: 10.12201/bmr.202504.00048

• ID	Submit time	Number	Download
  1	2025-02-06	bmr.202505.00023V1	Download

• Public  Anonymous  To author only Submit Comments