Clinical characteristics of premature rupture of membranes complicated with histological chorioamnionitis

Corresponding author: luo qingqing, luoqq822@126.com

DOI: 10.12201/bmr.202504.00048

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  Abstract: Abstract: Objective: To analyze the clinical features of premature rupture of membranes (PROM) complicated with histologic chorioamnionitis (HCA), and to provide insights for clinical management of such pregnant women and their newborns. Methods: A total of 202 cases of PROM pregnant women who gave birth in the Affiliated Hospital of Southwest Medical University from January 2021 to December 2021 were retrospectively analyzed. According to the histopathological results, the pregnant women were divided into HCA group and control group (151 cases vs. 51 cases), and the prenatal factors and short-term maternal-fetal pregnancy outcomes of the two groups were compared and analyzed. Results: The amniotic fluid contamination rate (19.6% 28/151 vs. 6.0% 3/51), white blood cell (WBC) count (10.26 vs. 9.72 *109//L), neutrophil (Neu) count (8.14 vs. 7.74*109//L) and serum amyloid A (SAA) levels (2.99 vs. 1.76 mg/L) in HCA group were significantly higher than those in control group (P<0.05). There was a higher?incidence of early neonatal septicemia in HCA group than in control group (49.7% 75/151 vs. 25.5% 13/51, P<0.05). Conclusion: The risk of early-onset sepsis in neonates with PROM complicated with HCA significantly increases. It is necessary to strengthen the screening and early intervention in such cases. Amniotic fluid contamination and increased maternal infection indicators are associated with the occurrence of HCA, which may serve as potential indicators of HCA.

  Key words: Histological chorioamnionitis; Premature rupture of membranes; Mother-child outcome.

  Submit time: 16 April 2025

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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