通讯作者: 高涛, eyes-on-you@163.com

DOI：10.12201/bmr.202505.00023

Research advances of natural killer cells at the maternal-fetal interface

• 摘要：目的 总结巨噬细胞及其极化在母胎界面的作用与其参与复发性流产发病的机制。方法 检索近10年PubMed、中国知网(China National Knowledge Infrastructure, CNKI)、Web of Science、万方等数据库中关于妊娠期巨噬细胞在母胎界面的作用的文献,归纳总结出巨噬细胞及其极化在母胎界面的作用与其参与自然流产发病的机制。结果 共检索到英文文献89篇,分析发现,巨噬细胞参与了滋养层侵袭、螺旋动脉重构及凋亡细胞的胞葬作用,M1/M2巨噬细胞的极化平衡是成功妊娠的必要条件,而妊娠期间M1/M2的失衡与自然流产或复发性流产密切相关。结论 以巨噬细胞为切入点,深入探讨其与正常妊娠及自然流产发病的具体机制,为发掘改善妊娠结局的新疗法提供新的靶点与思路。

  关键词： 蜕膜巨噬细胞; Hofbauer细胞; 妊娠; 母胎界面

   

  Abstract: Objective To summarize the role of macrophages and their polarization at the maternal fetal interface and their involvement in the pathogenesis of recurrent abortion. Methods The literatures on the role of macrophages in the maternal fetal interface during pregnancy in the databases of PubMed, China National Knowledge Infrastructure (CNKI),? web of science and Wanfang in recent 10 years were searched, and the role of macrophages and their polarization in the maternal fetal interface and their involvement in the pathogenesis of spontaneous abortion were summarized. results A total of 89 English literatures were retrieved. It was found that macrophages were involved in trophoblast invasion, spiral artery remodeling and the burial of apoptotic cells. The polarization balance of M1/M2 macrophages was a necessary condition for successful pregnancy, and the imbalance of M1/M2 during pregnancy was closely related to spontaneous abortion or recurrent abortion. Conclusion Taking macrophages as the starting point, this paper deeply discusses the specific mechanism between macrophages and normal pregnancy and spontaneous abortion, so as to provide new targets and ideas for exploring new therapies to improve pregnancy outcome.

  Key words: decidual macrophages; Hofbauer cells; Pregnancy; Maternal-fetal interface

  提交时间：2025-05-21

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• 序号	提交日期	编号	操作
  1	2025-02-06	bmr.202505.00023V1	下载

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