Analysis of Medication Patterns for Treating Menstrual Disorders with Chong and Ren Disharmony Based on Real-World Data Mining

Corresponding author: HU Xinxin, sunny-hxx@163.com

DOI: 10.12201/bmr.202412.00026

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  Abstract: Abstract: Objective This study employs real-world data mining techniques to analyze the medication patterns used by the Obstetrics and Gynecology team led by Ma Dazheng at Wenzhou TCM Hospital of Zhejiang Chinese Medical University for treating menstrual disorders with Chong and Ren dysfunction, offering valuable insights for clinical practice.. Methods Patient case data from the gynecology outpatient department of Wenzhou Traditional Chinese Medicine Hospital were collected from October 2023 to March 2024. A database was established based on the Traditional Chinese Medicine Inheritance Computer System (V3.0), and various data mining methods, including frequency statistics, association rule analysis, and cluster analysis, were employed to analyze the medication patterns in Traditional Chinese Medicine for treating menstrual disorders with Chong and Ren disharmony. Results A total of 9,003 valid medical cases and prescriptions were collected, involving 410 Chinese medicinal herbs. The top five herbs by frequency were Angelica sinensis, Cuscuta chinensis, Vinegar-processed Cyperus rotundus, Dipsacus asperoides, and Salvia miltiorrhiza. The most common categories of medication were tonifying herbs, blood-activating and stasis-resolving herbs, and heat-clearing herbs. The four qi distribution of medicinals was warm and cold, while the most frequent flavors were bitter and sweet. The meridians primarily involved were the liver and spleen. Association analysis revealed a core combination of herbs including Cuscuta chinensis, Lycium barbarum, Angelica sinensis, Dipsacus asperoides, and Vinegar-processed Cyperus rotundus. After cluster analysis, five effective groups were identified: Class I included Cuscuta chinensis, Angelica sinensis, Vinegar-processed Cyperus rotundus, Dipsacus asperoides, Caulis Spatholobus, and Lycium barbarum; Class II included Chaihu, Angelica sinensis, Poria, fried white peony root, fried Atractylodes macrocephala, and dandelion; Class III included raw Rehmannia, Angelica sinensis, Salvia miltiorrhiza, Dipsacus asperoides, Poria, and Vinegar-processed Cyperus rotundus; Class IV included Poria, Angelica sinensis, dried tangerine peel, Salvia miltiorrhiza, fried Atractylodes macrocephala, and Chuanxiong; Class V included licorice tablets, dandelion, Caulis Spatholobus, small thistle, large thistle, and fried mulberry bark. Conclusion The Obstetrics and Gynecology team led by Ma Dazheng at Wenzhou TCM Hospital of Zhejiang Chinese Medical University employs a treatment approach for menstrual disorders with Ren and Chong dysfunction that emphasizes the use of tonifying, invigorating blood, and heat-clearing medications, while focusing on the balance of the liver, spleen, and kidneys. Their prescribing strategy considers both superficial and underlying conditions, employs a gradual rather than abrupt approach, integrates both cold and warm remedies, and ensures mutual reinforcement and restriction among the treatments

  Key words: Menstrual disorders; Irregular menstruation; Chong and Ren disharmony; Ma Dazheng; Chinese medicine; Medication rule; Real world; Data mining

  Submit time: 9 December 2024

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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