Research value of SII and SIRI in prognostic assessment of patients with chronic heart failure complicated by renal dysfunction

Corresponding author: Xing Shifeng, xinjiang1313@163.com

DOI: 10.12201/bmr.202610.00031

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  Abstract: Abstract：Patients with chronic heart failure (CHF) complicated by renal dysfunction exhibit persistently elevated immune-inflammatory burden due to uremic toxin accumulation, oxidative stress, and endothelial injury, and their prognosis is worse than that of patients with heart failure alone. The systemic immune-inflammation index (SII) and the systemic inflammation response index (SIRI), derived from routine blood counts, are low-cost and reproducible. Current evidence indicates that elevated SII and SIRI are associated with all-cause death, cardiovascular death, heart failure rehospitalization, thrombotic events, and worsening renal function, and may provide supplementary information for the interpretation of treatment response in the context of sacubitril/valsartan and sodium-glucose cotransporter 2 (SGLT2) inhibitor therapy. However, SII and SIRI lack specificity, as they are susceptible to infection, anemia, and nutritional status; cutoffs and statistical methods vary across studies; and most existing studies are single-center, retrospective designs lacking external validation. At present, they should be regarded as risk-stratification and supplementary assessment tools used in combination with NT-proBNP and estimated glomerular filtration rate, and their exact value requires verification in multicenter, prospective studies.

  Key words: chronic heart failure complicated by renal dysfunction; systemic immune-inflammation index; systemic inflammation response index; inflammatory biomarker

  Submit time: 14 October 2026

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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  1	2026-07-19	10.12201/bmr.202610.00031V1	Download

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